Function

Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host (PubMed:25713147). Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422 (PubMed:15985609, PubMed:16817899, PubMed:19121323, PubMed:20066037, PubMed:21190553, PubMed:21423706). Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibition of processing of pre-PrcB and assembly of the proteasome complex, and thereby enhances the mycobacterial resistance to H(2)O(2); PknA thus plays an important role in the oxidative stress response by impeding the formation of holo-proteasome in M.tuberculosis under H(2)O(2) stress (PubMed:25224505). Shows a strong preference for Thr versus Ser as the phosphoacceptor. {ECO:0000269|PubMed:15985609, ECO:0000269|PubMed:16817899, ECO:0000269|PubMed:19121323, ECO:0000269|PubMed:20066037, ECO:0000269|PubMed:21190553, ECO:0000269|PubMed:21423706, ECO:0000269|PubMed:25224505, ECO:0000269|PubMed:25713147}.

Family

Protein kinase superfamily, Ser/Thr protein kinase family

GO

• protein autophosphorylation GO:0046777 biological_process
• pathogenesis GO:0009405 biological_process
• positive regulation of catalytic activity GO:0043085 biological_process
• negative regulation of catalytic activity GO:0043086 biological_process
• integral component of membrane GO:0016021 cellular_component
• protein kinase activity GO:0004672 molecular_function
• protein serine/threonine kinase activity GO:0004674 molecular_function
• negative regulation of lipid biosynthetic process GO:0051055 biological_process
• positive regulation of DNA binding GO:0043388 biological_process
• protein phosphorylation GO:0006468 biological_process
• plasma membrane GO:0005886 cellular_component
• regulation of cell shape GO:0008360 biological_process
• cytosol GO:0005829 cellular_component
• ATP binding GO:0005524 molecular_function
• extracellular region GO:0005576 cellular_component
• negative regulation of fatty acid biosynthetic process GO:0045717 biological_process

InterPro

• IPR011009
• IPR000719
• IPR008271

UniProt

P9WI83

GenBank

Rv0015c

EnsemblBacteria

Rv0015c

Mycobrowser

Rv0015c

Rv0015c doesn't seem to be a targeted by any drug.

Rv0015c doesn't seem to be involved in any pathway.