Gene - combatTB X

pbpA

Type: protein_coding
Name: pbpA
Locus Name: Rv0016c
Product: Probable penicillin-binding protein PbpA
Functional Category: Cell wall and cell processes
Location: 18759..20234 (- strand)
Gene Length: 1475 bp
Nucleotides: ATGAACGCCTCTCTGCGCCGAATATCGGTGACCGTGATGGCGTTGATCGTGTTGCTACTGCTCAACGCGACCATGACGCAGGTCTTCACCGCCGACGGGCTGCGTGCCGATCCCCGCAACCAGCGAGTGTTGCTCGACGAGTATTCACGGCAGCGCGGCCAGATCACCGCTGGTGGCCAACTGCTGGCGTACTCGGTAGCCACCGACGGCCGCTTTCGTTTCCTGCGGGTCTATCCCAATCCTGAGGTGTACGCGCCGGTTACCGGCTTCTACTCCCTGCGCTATTCCAGCACCGCCCTAGAACGAGCCGAGGACCCGATATTGAACGGGTCCGACCGCCGTCTGTTCGGCCGCCGGCTGGCCGACTTCTTCACCGGTCGCGACCCACGCGGCGGTAATGTCGATACCACGATCAACCCGCGCATTCAGCAAGCCGGCTGGGACGCGATGCAGCAAGGCTGCTACGGGCCCTGTAAGGGAGCGGTGGTCGCCCTTGAGCCATCAACCGGCAAGATTTTGGCGTTGGTGTCTTCTCCGTCCTACGACCCCAACCTGCTGGCGTCGCATAACCCCGAGGTGCAGGCGCAAGCCTGGCAGCGGCTTGGCGACAATCCCGCCTCTCCACTGACCAACCGTGCCATCTCTGAGACGTATCCACCGGGTTCGACTTTCAAAGTGATCACCACTGCGGCCGCGCTGGCCGCCGGGGCCACCGAGACCGAACAGCTGACTGCGGCGCCCACAATTCCGTTGCCAGGCAGCACCGCCCAGCTAGAGAACTACGGCGGTGCGCCGTGCGGGGACGAACCCACCGTGTCGCTGCGTGAGGCATTCGTCAAATCATGCAACACCGCATTCGTCCAGCTGGGCATCCGCACCGGCGCCGACGCCCTGCGCAGCATGGCGCGCGCGTTCGGTCTCGATAGCCCACCGCGCCCAACTCCGCTGCAAGTGGCGGAATCAACCGTCGGGCCTATCCCGGACAGCGCCGCACTAGGGATGACCAGTATCGGCCAAAAGGACGTTGCGCTGACCCCGCTAGCGAACGCAGAAATAGCCGCGACCATCGCAAACGGCGGCATTACGATGAGGCCTTATCTAGTCGGCAGCCTCAAGGGACCGGACCTAGCCAATATCTCAACCACCGTCGGATACCAGCAGCGCCGCGCGGTGTCACCGCAGGTCGCCGCTAAGCTAACAGAGCTGATGGTCGGCGCCGAGAAAGTCGCACAGCAGAAAGGGGCAATCCCCGGCGTGCAGATCGCATCCAAGACGGGCACCGCCGAACATGGCACCGACCCTCGTCACACTCCACCGCACGCTTGGTACATCGCCTTTGCGCCCGCACAAGCGCCCAAGGTGGCTGTTGCCGTGCTGGTGGAGAACGGGGCTGATCGGCTGTCCGCCACCGGAGGTGCCCTCGCGGCACCGATCGGGCGGGCGGTGATCGAAGCCGCACTGCAGGGGGAACCATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation.

Family

Transpeptidase family

GO

cell wall organization GO:0071555 biological_process
peptidoglycan biosynthetic process GO:0009252 biological_process
penicillin binding GO:0008658 molecular_function
cytosol GO:0005829 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
regulation of cell shape GO:0008360 biological_process

InterPro

UniProt: P9WKD1
GenBank: Rv0016c
EnsemblBacteria: Rv0016c
Mycobrowser: Rv0016c

Summary

Name: Penicillin-binding protein A (PBPA)
Family: Transpeptidase family
Protein Sequence: MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP
Mass: 51,576 Da
Length: 491 Aa

Rv0016c doesn't seem to be a targeted by any drug.

Peptidoglycan biosynthesis mtu00550
mtu00550
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division.: Microbiology. 2006 Feb;152(Pt 2):493-504. doi: 10.1099/mic.0.28630-0.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.