fhaA
- Type
- protein_coding
- Name
- fhaA
- Locus Name
-
Rv0020c
- Product
-
Conserved protein with FHA domain, FhaA
- Functional Category
-
Regulatory proteins
- Location
- 23861..25444 (- strand)
- Gene Length
- 1583 bp
- Nucleotides
-
ATGGGTAGCCAGAAAAGGCTGGTTCAGCGCGTTGAGCGCAAACTCGAGCAGACGGTTGGCGATGCGTTTGCCCGCATCTTTGGAGGCTCGATCGTCCCGCAAGAGGTCGAAGCCCTGCTGCGCCGCGAGGCGGCCGACGGCATCCAGTCGCTGCAGGGAAATCGCCTTTTGGCGCCCAACGAATACATCATTACCCTCGGTGTGCACGACTTTGAGAAGTTGGGCGCTGATCCTGAGCTGAAGTCAACCGGTTTTGCTCGGGACTTGGCGGACTATATCCAAGAACAGGGGTGGCAAACGTATGGTGATGTGGTCGTCCGATTCGAGCAGTCGTCGAACCTGCATACCGGCCAGTTCCGCGCCCGCGGCACTGTTAACCCCGACGTTGAGACCCACCCGCCGGTCATCGATTGCGCCCGGCCACAATCAAACCACGCGTTTGGCGCAGAACCAGGAGTAGCACCAATGAGTGACAATTCGAGCTACCGTGGCGGTCAGGGGCAGGGGCGTCCCGACGAGTATTACGACGACCGCTATGCGCGTCCGCAAGAGGATCCGCGTGGTGGCCCGGATCCGCAAGGCGGATCTGACCCCCGCGGGGGGTATCCACCCGAGACGGGCGGCTACCCGCCCCAGCCGGGCTACCCACGCCCGCGCCACCCGGACCAGGGCGACTACCCCGAGCAAATCGGGTACCCCGACCAGGGCGGTTACCCCGAGCAACGCGGTTACCCCGAGCAACGCGGCTACCCCGACCAGCGCGGGTACCAGGACCAGGGTCGAGGCTACCCCGACCAAGGGCAGGGGGGCTATCCGCCGCCCTACGAGCAACGCCCTCCTGTTTCTCCCGGCCCGGCTGCCGGCTACGGCGCTCCCGGCTACGACCAGGGCTATCGCCAAAGCGGCGGCTACGGCCCTTCACCCGGTGGCGGCCAGCCCGGCTACGGCGGGTACGGGGAGTACGGGCGTGGCCCGGCTCGCCACGAGGAGGGCAGCTATGTGCCCTCTGGCCCTCCGGGCCCGCCCGAGCAACGACCGGCTTACCCCGACCAAGGCGGTTACGACCAGGGCTACCAGCAAGGCGCCACGACATACGGCCGGCAAGACTATGGCGGCGGCGCTGACTACACCCGCTACACCGAATCCCCGCGGGTCCCGGGATACGCTCCTCAGGGTGGCGGGTACGCCGAACCCGCCGGCCGAGACTACGACTACGGCCAATCAGGCGCTCCGGACTACGGTCAGCCAGCGCCCGGTGGCTACAGCGGTTACGGGCAGGGCGGCTATGGGTCCGCCGGAACGTCGGTTACGCTGCAGCTCGACGACGGCAGCGGACGCACTTACCAGCTCCGCGAGGGCTCCAACATCATCGGTCGCGGACAGGACGCCCAGTTCCGGCTGCCCGACACCGGTGTGTCACGCCGTCACTTGGAGATCCGGTGGGACGGGCAGGTCGCATTGCTCGCAGACCTGAACTCCACCAACGGCACCACTGTTAACAATGCACCGGTACAGGAGTGGCAGTTGGCCGACGGTGATGTGATCCGCTTGGGACACTCCGAGATCATCGTCCGCATGCACTG
- Drug Resistance
- Mutations
- Function
- Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. {ECO:0000269|PubMed:22275220}.
- Family
-
Unknown
- GO
-
- mRNA binding GO:0003729 molecular_function
- cell wall GO:0005618 cellular_component
- cytosol GO:0005829 cellular_component
- InterPro
2LC0
- Name
- FHA domain-containing protein FhaA
- Family
- Unknown
- Protein Sequence
-
MGSQKRLVQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLLAPNEYIITLGVHDFEKLGADPELKSTGFARDLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRARGTVNPDVETHPPVIDCARPQSNHAFGAEPGVAPMSDNSSYRGGQGQGRPDEYYDDRYARPQEDPRGGPDPQGGSDPRGGYPPETGGYPPQPGYPRPRHPDQGDYPEQIGYPDQGGYPEQRGYPEQRGYPDQRGYQDQGRGYPDQGQGGYPPPYEQRPPVSPGPAAGYGAPGYDQGYRQSGGYGPSPGGGQPGYGGYGEYGRGPARHEEGSYVPSGPPGPPEQRPAYPDQGGYDQGYQQGATTYGRQDYGGGADYTRYTESPRVPGYAPQGGGYAEPAGRDYDYGQSGAPDYGQPAPGGYSGYGQGGYGSAGTSVTLQLDDGSGRTYQLREGSNIIGRGQDAQFRLPDTGVSRRHLEIRWDGQVALLADLNSTNGTTVNNAPVQEWQLADGDVIRLGHSEIIVRMH
- Mass
- 56,880 Da
- Length
- 527 Aa
Summary
Rv0020c doesn't seem to be a targeted by any drug.
Rv0020c doesn't seem to be involved in any pathway.
- A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.
- Sci Signal. 2012 Jan 24;5(208):ra7. doi: 10.1126/scisignal.2002525.
- Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase.
- Structure. 2011 Oct 12;19(10):1525-34. doi: 10.1016/j.str.2011.07.011.
- Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
- Structure. 2010 Dec 8;18(12):1587-95. doi: 10.1016/j.str.2010.09.014.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Mycobacterium tuberculosis serine/threonine kinases PknB, PknD, PknE, and PknF phosphorylate multiple FHA domains.
- Protein Sci. 2005 Jul;14(7):1918-21. doi: 10.1110/ps.051413405.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.