Gene - combatTB X

ino1

Type: protein_coding
Name: ino1
Locus Name: Rv0046c
Product: myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)
Functional Category: Intermediary metabolism and respiration
Location: 50021..51124 (- strand)
Gene Length: 1103 bp
Nucleotides: ATGAGTGAGCACCAGTCGTTACCGGCGCCGGAGGCGTCGACGGAGGTTCGAGTCGCCATTGTCGGCGTCGGCAACTGCGCGTCCTCGCTGGTCCAGGGCGTCGAGTACTACTACAACGCCGACGACACATCGACCGTACCGGGCCTCATGCACGTGCGGTTCGGCCCGTACCACGTTCGCGACGTCAAGTTCGTGGCGGCGTTCGACGTGGACGCCAAGAAGGTCGGCTTCGACCTGTCCGACGCCATCTTCGCCTCGGAGAACAACACCATCAAGATCGCCGATGTGGCGCCGACCAACGTGATCGTGCAGCGCGGGCCTACCCTCGATGGCATCGGCAAGTACTACGCCGACACCATCGAACTCTCCGACGCGGAGCCCGTCGACGTCGTCCAGGCGCTCAAGGAGGCCAAGGTCGACGTGCTGGTCTCCTATTTGCCGGTGGGCTCGGAGGAAGCCGACAAGTTCTACGCCCAGTGTGCTATCGACGCCGGGGTGGCGTTCGTCAACGCGCTGCCGGTGTTCATCGCCTCCGACCCGGTGTGGGCCAAGAAGTTCACCGACGCCAGGGTACCCATCGTCGGTGATGACATCAAGAGCCAGGTCGGCGCGACGATCACCCACCGGGTGCTGGCCAAGCTGTTCGAGGACCGCGGCGTGCAGCTCGACCGCACCATGCAGCTCAACGTGGGCGGCAACATGGACTTCCTCAACATGCTCGAACGTGAACGGCTGGAGTCCAAGAAGATCTCCAAGACCCAGGCCGTCACTTCGAATCTGAAGCGCGAGTTCAAGACCAAGGACGTGCACATCGGCCCGTCCGACCACGTCGGATGGCTCGACGATCGCAAATGGGCCTATGTCCGTCTTGAGGGCCGCGCCTTCGGAGATGTGCCGTTGAACCTGGAGTACAAGCTCGAGGTGTGGGACTCGCCAAACTCGGCCGGCGTCATCATCGACGCGGTGCGGGCGGCCAAGATCGCCAAGGACCGCGGCATCGGCGGACCGGTGATCCCGGCGTCGGCCTACCTGATGAAGAGCCCGCCCGAGCAGCTGCCCGACGACATCGCGCGCGCGCAACTCGAAGAGTTCATCATCGGTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate. {ECO:0000250}.

Family

Myo-inositol 1-phosphate synthase family

GO

mycothiol biosynthetic process GO:0010125 biological_process
pathogenesis GO:0009405 biological_process
inositol biosynthetic process GO:0006021 biological_process
phospholipid biosynthetic process GO:0008654 biological_process
cytosol GO:0005829 cellular_component
zinc ion binding GO:0008270 molecular_function
inositol-3-phosphate synthase activity GO:0004512 molecular_function

InterPro

UniProt: P9WKI1
GenBank: Rv0046c
EnsemblBacteria: Rv0046c
Mycobrowser: Rv0046c

Summary

Name: Inositol-3-phosphate synthase (IPS) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase)
Family: Myo-inositol 1-phosphate synthase family
Protein Sequence: MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
Mass: 40,094 Da
Length: 367 Aa

Rv0046c doesn't seem to be a targeted by any drug.

Mycothiol biosynthesis R-MTU-879299
Mycobacterium tuberculosis
cytosol

Streptomycin biosynthesis mtu00521
mtu00521
Metabolism; Biosynthesis of other secondary metabolites

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .: PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.