Gene - combatTB X

Rv0143c

Type: protein_coding
Name: Rv0143c
Locus Name: Rv0143c
Product: Probable conserved transmembrane protein
Functional Category: Cell wall and cell processes
Location: 168704..170182 (- strand)
Gene Length: 1478 bp
Nucleotides: ATGGCGCCGGGCGACTGGTCGGTGTTCGCTTGGCATGCTGCTAACCTCCCGACCATGCCGGAGGCGGAAGACATCGGGAACGAGGCCGCCGGCGGACGATTCGGCGTATCGATCAGGAGCGCGGGCTACCTGCGCAAATGGTTCCTGCTAGGCATCACGATCGGTGTCATTGCCGGCCTGGGCGCCGTCGTCTTCTACCTCGCGCTGAAATACACCAGCGAGTTTCTGCTCGGCTACCTCGCGGACTATCAGATTCCCACTCCCGTTGGGGAGGGCGGCCACCGCGGGTCCACCGGTTTCGCGCGTCCGTGGGCGATTCCGCTGGTGACGACGGGCGGGGCGGTGCTGTCGGCATTGATCGTGGCCAAGCTCGCCCCGGAGGCCACCGGTCACGGCACCGACGAAGCGATCGAGTCGGTGCACGGCGATCCGCGCGCCATCCGAGGTCGGGCGGTGCTGGTGAAGATGGTGGCCAGCGCCTTGACCATCGGCTCGGGCGGTTCAGGCGGCCGCGAAGGCCCGACCGCGCAGATCTCGGCCGGCTTCTGCTCACTGCTGACCCGCCGGCTGAACCTGTCCAACGAAGACGGCCGGACCGCGGTAGCGCTGGGTATCGGCGCCGGCATCGGCGCCATCTTCGCTGCGCCACTGGGCGGAGCGGCGTTGGGCGCCTCGATCCCCTACCGCGACGACTTCGACTACCGCAACCTGCTGCCGGGTTTCATCGCCTCGGGAACCGCCTACGCCGTGCTCGGCGCCTTCTTGGGCTTCGACCCGCTGTTCGGCTACATCGACGCCGAGTATCGCTTCGAAAAGGCGTGGCCACTACTGTGGTTCGTGGTGATCGGGCTGATCGCAGCCGCCGTAGGCTACTTGTATGCCCGAGTCTTTCACGCGTCGGTGGCAATTACGCGCCGGCTGCCCGGGGGCCCGGTGCTCAAACCGGCGATCGGCGGACTGCTGGTCGGGCTGTTAGGTCTGCCGATTCCCCAGATCCTGAGCAGCGGCTATGGCTGGGCGCAGCTAGCCGCCGATCGGGGGACGCTGCTGAGCATCCCGTTGTGGATCGTCATCGTCTTGCCGATCGCCAAGATCCTCGCGACGTCGCTGTCGATCGGCACCGGCGGATCAGGCGGGCTATTCGGGCCGGGAATCGTGATCGGCGCCTTCGTCGGAGCGGCGATCTGGCGGCTAGGCGAGCTCACCGAGCTGCCCGGGGTGCCCCACGAGCCGGGCATCTTCGTCGTGGTCGCAATGATGGCGTGCTTCGGCAGTGTCTCCCGCGCGCCGCTGGCCGTCATGATCATGGTCGCTGAGATGACCGGCTCGTTCTCGGTGGTGCCTGGAGCGATCATCGCCGTCGGTATCGCGGCACTGTTGTTGTCTCGCACCAACGTCACCATCTACGAGACGCAGCGACTGAACCGGCAGACCGCCGAGGCCGAACGCGGAGGCAGTGATCGGCCGACAACGGCTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

voltage-gated chloride channel activity GO:0005247 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P96820
GenBank: Rv0143c
EnsemblBacteria: Rv0143c
Mycobrowser: Rv0143c

Summary

Name: Probable conserved transmembrane protein
Family: Unknown
Protein Sequence: MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYLRKWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGFARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
Mass: 50,808 Da
Length: 492 Aa

Rv0143c doesn't seem to be a targeted by any drug.

Rv0143c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.