Gene - combatTB X

PE3

Type: protein_coding
Name: PE3
Locus Name: Rv0159c
Product: PE family protein PE3
Functional Category: Pe/ppe
Location: 187433..188839 (- strand)
Gene Length: 1406 bp
Nucleotides: ATGTCCTACGTCATCGCGGCCCCGGAGATGTTGGCAACGACGGCCGCGGACGTGGACGGGATCGGTTCGGCGATACGAGCGGCCAGCGCGTCCGCTGCGGGTCCAACGACCGGACTGCTGGCCGCGGCCGCCGATGAGGTGTCGTCGGCCGCTGCAGCGCTGTTCAGCGAATACGCGCGCGAATGTCAAGAGGTCCTAAAGCAGGCTGCGGCGTTCCATGGCGAGTTCACCCGGGCGCTGGCTGCCGCCGGGGCCGCCTATGCCCAGGCTGAAGCCAGCAACACCGCTGCTATGTCGGGCACCGCCGGGTCCAGCGGCGCCCTCGGTTCTGTCGGGATGCTGTCAGGCAACCCGCTAACCGCGTTGATGATGGGCGGCACCGGGGAACCGATCCTTAGTGACCGCGTCTTGGCGATCATTGACAGCGCATACATTCGGCCCATTTTCGGGCCCAACAACCCGGTCGCCCAGTACACGCCCGAGCAGTGGTGGCCGTTTATCGGGAACCTGTCACTGGACCAATCCATCGCCCAGGGTGTCACGCTGCTGAACAACGGCATCAACGCGGAACTACAAAATGGGCATGACGTCGTCGTTTTCGGCTACTCGCAAAGCGCCGCGGTAGCGACCAATGAAATACGCGCTCTTATGGCGTTACCACCGGGCCAAGCCCCAGATCCAAGCCGGCTGGCTTTCACGTTGATCGGTAATATCAATAACCCCAACGGCGGCGTCCTCGAGCGTTACGTGGGCCTTTACCTCCCGTTCTTGGATATGTCGTTCAACGGTGCGACTCCACCGGATTCCCCCTACCAGACCTACATGTACACCGGCCAATACGACGGCTACGCCCACAACCCGCAGTACCCGCTCAATATCTTGTCGGACCTCAACGCCTTCATGGGCATCAGATGGGTGCACAACGCGTACCCCTTCACCGCGGCCGAGGTTGCCAATGCCGTGCCGTTGCCCACGTCTCCGGGCTACACCGGCAACACCCATTACTACATGTTTCTGACCCAGGACCTGCCGCTGTTGCAGCCGATTCGCGCCATCCCCTTCGTAGGGACCCCAATAGCCGAGCTGATTCAGCCCGACCTACGGGTGCTAGTCGACTTGGGCTATGGCTACGGCTACGCCGACGTACCCACCCCGGCCAGCCTGTTCGCGCCAATCAACCCGATCGCCGTGGCCTCGGCCCTGGCGACCGGGACCGTGCAAGGCCCCCAAGCCGCCCTAGTAAGCATCGGATTGTTACCGCAGTCCGCGCTACCCAATACGTATCCGTATCTTCCGTCGGCGAATCCGGGCCTGATGTTCAACTTCGGTCAATCCAGTGTGACGGAGTTGTCGGTGCTCAGTGGCGCCCTCGGGTCCGTAGCGAGATTGATTCCACCGATCGCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Plays significant roles in mycobacterial persistence during infection and modulates host immune response. {ECO:0000269|PubMed:23708146}.

Family

Mycobacterial PE family

GO

pathogenesis GO:0009405 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component

InterPro

UniProt: Q79G04
GenBank: Rv0159c
EnsemblBacteria: Rv0159c
Mycobrowser: Rv0159c

Summary

Name: PE family protein PE3
Family: Mycobacterial PE family
Protein Sequence: MSYVIAAPEMLATTAADVDGIGSAIRAASASAAGPTTGLLAAAADEVSSAAAALFSEYARECQEVLKQAAAFHGEFTRALAAAGAAYAQAEASNTAAMSGTAGSSGALGSVGMLSGNPLTALMMGGTGEPILSDRVLAIIDSAYIRPIFGPNNPVAQYTPEQWWPFIGNLSLDQSIAQGVTLLNNGINAELQNGHDVVVFGYSQSAAVATNEIRALMALPPGQAPDPSRLAFTLIGNINNPNGGVLERYVGLYLPFLDMSFNGATPPDSPYQTYMYTGQYDGYAHNPQYPLNILSDLNAFMGIRWVHNAYPFTAAEVANAVPLPTSPGYTGNTHYYMFLTQDLPLLQPIRAIPFVGTPIAELIQPDLRVLVDLGYGYGYADVPTPASLFAPINPIAVASALATGTVQGPQAALVSIGLLPQSALPNTYPYLPSANPGLMFNFGQSSVTELSVLSGALGSVARLIPPIA
Mass: 48,608 Da
Length: 468 Aa

Rv0159c doesn't seem to be a targeted by any drug.

Rv0159c doesn't seem to be involved in any pathway.

Putative roles of a proline-glutamic acid-rich protein (PE3) in intracellular survival and as a candidate for subunit vaccine against Mycobacterium tuberculosis.: Med Microbiol Immunol. 2013 Oct;202(5):365-77. doi: 10.1007/s00430-013-0299-9. Epub 2013 May 25.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.