sigG
- Type
- protein_coding
- Name
- sigG
- Locus Name
-
Rv0182c
- Product
-
Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor)
- Functional Category
-
Information pathways
- Location
- 213028..214140 (- strand)
- Gene Length
- 1112 bp
- Nucleotides
-
ATGCGCACATCGCCGATGCCCGCGAAATTCCGTTCAGTCCGGGTGGTAGTCATTACCGGGAGCGTAACGGCTGCTCCGGTGAGAGTGTCGGAGACTCTGCGTAGGCTCATTGACGTGAGTGTGCTCGCAGAAAACTCTGGCCGCGAGCCCGCCGACGAACGGCGCGGGGACTTCTCCGCCCACACCGAGCCCTACCGGCGTGAACTGCTCGCACACTGCTATCGCATGACTGGCTCGCTGCACGACGCGGAAGACCTTGTTCAGGAGACGCTGCTGCGGGCCTGGAAGGCCTATGAGGGCTTCGCGGGCAAGTCCTCGCTACGCACCTGGCTGCATCGGATCGCCACCAACACCTGCCTGACGGCGTTGGAGGGCCGTCGACGCCGGCCGTTGCCGACGGGGCTCGGGCGGCCGAGTGCCGATCCGTCCGGGGAGTTGGTGGAACGTCGAGAGGTGTCCTGGCTGGAGCCGCTGCCGGACGTGACGGACGACCCTGCTGATCCCTCAACGATCGTCGGGAACCGGGAATCGGTGCGGTTGGCCTTTGTGGCGGCTCTGCAGCACCTCTCACCCCGGCAGCGAGCCGTACTGCTGCTGCGCGACGTGCTGCAGTGGAAATCGGCCGAGGTGGCCGACGCGATCGGTACCAGCACCGTCGCCGTCAATAGCCTGCTGCAGCGGGCCCGCTCTCAGCTGCAGACGGTCCGGCCCAGCGCCGCCGACCGGTTGTCCGCGCCGGATTCACCCGAGGCGCAAGACCTGTTGGCCCGCTATATCGCCGCGTTCGAGGCTTATGACATCGACCGGTTGGTCGAGCTGTTCACCGCCGAGGCGATCTGGGAAATGCCGCCGTATACCGGCTGGTACCAGGGCGCACAGGCCATCGTCACCCTCATTCACCAACAGTGCCCCGCCTATTCGCCTGGCGATATGCGCCTGATTTCGTTGATCGCCAACGGCCAGCCCGCCGCGGCCATGTACATGCGTGCCGGTGACGTGCACCTGCCTTTTCAGCTACACGTGCTGGACATGGCCGCCGACCGCGTGTCACACGTGGTGGCCTTCCTCGACACCACCTTGTTCCCGAAATTCGGCCTGCCCGATTCGCTGTG
- Drug Resistance
- Mutations
- Function
- Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein. May be involved in host intracellular survival after infection (strains H37Rv and CDC 1551). A role in the SOS response is controversial; it has been seen in strain CDC 1551 (PubMed:18039768) but not in H37Rv (PubMed:21169493). {ECO:0000269|PubMed:16483748, ECO:0000269|PubMed:21169493}.
- Family
-
Sigma-70 factor family, ECF subfamily
- GO
-
- sigma factor activity GO:0016987 molecular_function
- response to hypoxia GO:0001666 biological_process
- DNA-templated transcription, initiation GO:0006352 biological_process
- DNA binding GO:0003677 molecular_function
- DNA-binding transcription factor activity GO:0003700 molecular_function
- response to water GO:0009415 biological_process
- InterPro
Summary
- Name
- ECF RNA polymerase sigma factor SigG (ECF sigma factor SigG) (Alternative RNA polymerase sigma factor SigG) (RNA polymerase sigma-G factor) (Sigma-g factor)
- Family
- Sigma-70 factor family, ECF subfamily
- Protein Sequence
-
MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAENSGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAWKAYEGFAGKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGELVERREVSWLEPLPDVTDDPADPSTIVGNRESVRLAFVAALQHLSPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVNSLLQRARSQLQTVRPSAADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWEMPPYTGWYQGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGDVHLPFQLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL
- Mass
- 40,983 Da
- Length
- 370 Aa
Rv0182c doesn't seem to be a targeted by any drug.
Rv0182c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- SigG does not control gene expression in response to DNA damage in Mycobacterium tuberculosis H37Rv.
- J Bacteriol. 2011 Feb;193(4):1007-11. doi: 10.1128/JB.01241-10. Epub 2010 Dec 17.
- Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function.
- Res Microbiol. 2006 Jun;157(5):445-55. doi: 10.1016/j.resmic.2005.10.007. Epub 2006 Jan 13.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.
- Mol Microbiol. 1999 Jan;31(2):715-24.