Gene - combatTB X

mmpL11

Type: protein_coding
Name: mmpL11
Locus Name: Rv0202c
Product: Probable conserved transmembrane transport protein MmpL11
Functional Category: Cell wall and cell processes
Location: 238392..241292 (- strand)
Gene Length: 2900 bp
Nucleotides: ATGATGCGCTTGAGCCGCAACCTGCGCAGGTGCCGTTGGTTGGTCTTCACGGGTTGGTTGCTGGCGTTAGTGCCGGCGGTTTACCTGGCGATGACGCAGTCGGGGAATCTAACCGGTGGCGGTTTCGAAGTCGCCGGGTCGCAGTCATTGCTGGTCCACGACCAACTCGACGCGCACTACCCGGACCGGGGAGCCCCGGCGCTGGCGCTGGTAGCGGCCCCCCGACCGGATGCTAGCTACCAAGACATCGACAATGCCGTCGCGCTACTGCGACAAATAGCCAGCGAACTGCCTGGGGTGACGGAGGCACCCAACCCCACCCAACGGCCCCCGCAACCGGACCGGCCGTATGTGGTGTCGCTGCGGCTGGACGCCCGCAACGCGGGCACCAGTGACGTCGCCAAAAAGCTGCGCGACCGAATAGGCGTCAAAGGCGATCAGTCCGGGCAAACTGCCAACGGCAAAGTGCGGCTCTATGTCATCGGGCAGGGCGCGCTGTCCGCGGCCGCGGCGGCAAACACCAAACACGATATTGCCAACGCCGAACGCTGGAACCTGCCTATCATTCTGATGGTCCTGGTTGCGGTTTTCGGCTCGTTGGCCGCCGCAGCGATCCCGCTGGCACTCGCCGTTTGCACGGTCGTCATCACCATGGGCCTGGTGTTTGTGTTGTCGATGCACACCACCATGTCGGTGTTCGTGACATCGACCGTTTCGATGTTCGGCATCGCGCTTGCCGTCGACTACTCCCTGTTCATCCTGATGCGCTACCGCGAGGAACTGCGTTGCGGACGCCGGCCGCCCGACGCGGTCGACGCCGCGATGGCCACTTCGGGGTTGGCTGTGGTGTTGTCCGGTATGACGGTCATCGCGTCGCTGACCGGGATCTACCTGATCAACACCCCGGCGCTGAGATCGATGGCCACCGGGGCGATTCTCGCGGTCGCGGTTGCGATGCTGACGTCGGCCACCCTGACACCTGCCGTGCTAGCAACATTTGCCCGCGCGGCGGCCAAGCGGTCAGCGTTAGTGCACTGGTCGCGGCGGCCGGCAAGCACGCAATCTTGGTTCTGGTCCCGCTGGGTCGGGTGGGTGATGCGCCGACCCTGGATCACAGCACTGGCGGCATCGACCGTGCTGCTTGTCATGGCGGCACCGGCAACCTTGATGGTGCTGGGCAACAGCTTGCTGCGCCAGTTCGACTCGTCACACGAGATCCGCACCGGCGCAGCGGCCGCGGCCCAAGCGCTGGGGCCGGGCGCGCTGGGCCCGGTTCAGGTGCTGGTCAGGTTTGACGCCGGCGGTGCGTCCGCACCCGAACATAGCCAGACAATCGCCGCAATCCGTCATCGGATCGCACAGGCGCCCAACGTCGTTTCGGTGGCCCCACCGCGATTCGCCGACGACAACGGCAGCGCTTTGCTCAGCGCGGTGCTATCGGTCGATCCCGAGGATTTGGGCGCCCGCGACACCATCACCTGGATGCGGACCCAGCTACCCCGGGTTGCCGGCGCGGCACAAGTGGACGTCGGCGGGCCGACCGCTCTGATCAAGGATTTCGACGACCGGGTGTCCGCGACGCAACCGCTGGTGCTGGTCTTCGTGGCGGTGATCGCGTTTTTGATGTTGTTGATCTCAATCCGCTCGGTGTTCCTGGCGTTCAAGGGCGTGCTGATGACGCTGCTGTCGGTGGCCGCCGCCTACGGCAGCCTGGTGATGGTCTTCCAGTGGGGCTGGGCACGGGGGCTCGGTTTCCCGGCGCTTCATTCGATCGACAGCACCGTTCCCCCGCTGGTCCTGGCGATGACGTTCGGGTTGTCGATGGACTATGAAATCTTCCTGCTTACGCGAATCCGGGAGCGGTTCCTGCAGACGGGCCAGACCCGCGACGCGGTCGCGTACGGTGTGCGCACCAGCGCGCGCACGATCACCAGCGCCGCGTTGATCATGATCGCGGTGTTTTGCGGGTTCGCGTTCGCCGGCATGCCGCTAGTGGCCGAGATCGGCGTGGCGTGCGCGGTCGCGATCGCCGTGGACGCCACCGTCGTGCGGCTGGTGCTGGTACCGGCATTGATGGCGATGTTTGACCGATGGAACTGGTGGTTGCCCCGATGGCTGGCCCACATCTTGCCGTCGGTCGACTTCGACCGACCGCTGCCGAAAGTCGACCTCGGTGACGTCGTGGTCATTCCTGACGACTTCGCCGCGGCGATCCCGCCCAGCGCGGATGTGCGGATGGTGCTCAAGTCGGCGGCCAAGCTCAAGCGACTTGCGCCGGACGCCATTTGCGTTACCGATCCGCTCGCCTTCACCGGGTGTGGATGTGACGGTAAGGCGCTCGACCAGGTGCAGCTGGCCTACCGCAACGGCATCGCCCGGGCGATATCATGGGGCCAGCGCCCGGTGCACCCGGTCACCGTGTGGCGCAAGCGGCTCGCGGTCGCCCTCGACGCGCTTCAGACAACCACCTGGGAGTGCGGGGGGGTGCAGACTCACCGGGCGGGCCCCGGCTACCGGCGGCGCAGCCCGGTGGAGACGACCAACGTCGCATTGCCCACCGGTGACCGCTTGCAGATCCCAACCGGCGCGGAAACGCTGCGCTTCAAGGGCTACCTGATCATGTCCCGAAACAGCAGCCACGACTACGCCGACTTTGCTGACCTGGTCGATACGATGGCACCCGAAACCGCCGCCGCGGTGCTGGCTGGGATGGATCGGTACTACTCTTGTCAAGCACCCGGGCGGCAATGGATGGCCACCCAGTTGGTTGGTCGCCTGGCAGATCCGCAACCGTCTGACCTCGGTGACCAGTCGCCCGGAGCTGATGCCCAGGCAAAGTGGGAAGAGGTCCGGCGGCGTTGCCTGTCGGTGGCCGTGGCGATGTTGGAGGAGGCGAGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell. Contributes to virulence. {ECO:0000269|PubMed:15908378, ECO:0000269|PubMed:21383189, ECO:0000269|PubMed:23760277}.; FUNCTION: Could also transport the mycolic acid-containing lipids monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to the bacterial surface. {ECO:0000303|PubMed:23836904}.

Family

Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily

GO

pathogenesis GO:0009405 biological_process
cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WJT9
GenBank: Rv0202c
EnsemblBacteria: Rv0202c
Mycobrowser: Rv0202c

Summary

Name: Heme uptake protein MmpL11
Family: Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily
Protein Sequence: MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
Mass: 103,502 Da
Length: 966 Aa

Rv0202c doesn't seem to be a targeted by any drug.

Rv0202c doesn't seem to be involved in any pathway.

MmpL11 protein transports mycolic acid-containing lipids to the mycobacterial cell wall and contributes to biofilm formation in Mycobacterium smegmatis.: J Biol Chem. 2013 Aug 16;288(33):24213-22. doi: 10.1074/jbc.M113.473371. Epub 2013 Jul 8.
The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.: J Biol Chem. 2013 Jul 26;288(30):21714-28. doi: 10.1074/jbc.M113.453076. Epub 2013 Jun 11.
Discovery and characterization of a unique mycobacterial heme acquisition system.: Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5051-6. doi: 10.1073/pnas.1009516108. Epub 2011 Mar 7.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.: Infect Immun. 2005 Jun;73(6):3492-501. doi: 10.1128/IAI.73.6.3492-3501.2005.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.