Gene - combatTB X

fabG4

Type: protein_coding
Name: fabG4
Locus Name: Rv0242c
Product: Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Functional Category: Lipid metabolism
Location: 290665..292029 (- strand)
Gene Length: 1364 bp
Nucleotides: GTGGCTCCCAAGCGTTCGTCCGATCTGTTCTCGCAGGTTGTCAACTCCGGTCCAGGATCGTTTTTGGCCAGGCAATTGGGTGTTCCGCAACCCGAGACGCTTCGCCGCTATCGAGCAGGCGAACCGCCACTGACCGGGTCGCTGCTGATCGGCGGGGCCGGCAGGGTCGTCGAACCACTGCGCGCGGCACTCGAAAAGGACTACGACCTGGTAGGAAACAACCTGGGCGGGCGCTGGGCGGACTCGTTCGGCGGGCTGGTCTTCGACGCCACCGGCATCACAGAGCCGGCCGGGCTCAAGGGGCTGCACGAGTTCTTTACTCCGGTACTGCGCAATCTCGGCCGTTGCGGGCGCGTGGTGGTTGTTGGCGGCACACCCGAAGCGGCCGCCAGCACGAACGAGCGGATCGCGCAGCGCGCGCTGGAGGGCTTCACCCGCTCGCTGGGCAAGGAACTGCGCCGCGGTGCGACAACGGCGTTGGTCTACCTGTCGCCGGACGCCAAGCCCGCAGCTACCGGCCTCGAGTCGACCATGCGATTCCTGCTGTCGGCCAAGTCGGCCTACGTCGACGGCCAAGTCTTCTCTGTCGGGGCGGACGATTCCACACCGCCGGCCGACTGGGAGAAGCCGCTGGACGGCAAGGTCGCCATTGTGACCGGCGCGGCCCGCGGCATCGGCGCAACCATCGCCGAGGTGTTCGCTCGCGACGGCGCCCACGTGGTCGCCATCGATGTGGAGTCCGCCGCCGAGAACCTGGCCGAAACCGCCAGCAAGGTGGGCGGCACCGCGCTGTGGCTCGACGTCACCGCCGACGATGCCGTCGACAAGATCAGCGAGCACCTGCGCGACCACCACGGTGGCAAGGCCGACATCCTGGTCAACAACGCCGGCATCACCCGTGACAAGCTGCTGGCCAACATGGACGATGCGCGTTGGGACGCCGTCCTGGCTGTCAATCTGCTTGCCCCGTTGCGGCTCACCGAGGGTCTGGTGGGCAACGGCAGCATCGGAGAGGGTGGTCGGGTGATCGGGCTGTCGTCGATCGCCGGCATCGCCGGCAACCGCGGCCAGACCAACTACGCCACCACCAAGGCCGGGATGATCGGCATCACCCAGGCGCTGGCACCCGGCCTGGCCGCGAAAGGCATCACGATCAACGCCGTGGCACCGGGATTCATCGAAACCCAGATGACGGCCGCCATCCCGCTGGCCACCCGTGAGGTAGGCCGCCGGCTGAACTCGCTGCTGCAGGGCGGGCAGCCCGTCGACGTCGCCGAGGCCATCGCCTACTTCGCCAGCCCGGCGTCAAACGCGGTGACCGGCAACGTCATTCGTGTCTGCGGCCAGGCCATGATCGGCGCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

oxidation-reduction process GO:0055114 biological_process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 molecular_function

InterPro

UniProt: I6Y778
GenBank: Rv0242c
EnsemblBacteria: Rv0242c
Mycobrowser: Rv0242c

Summary

Name: Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Family: Unknown
Protein Sequence: MAPKRSSDLFSQVVNSGPGSFLARQLGVPQPETLRRYRAGEPPLTGSLLIGGAGRVVEPLRAALEKDYDLVGNNLGGRWADSFGGLVFDATGITEPAGLKGLHEFFTPVLRNLGRCGRVVVVGGTPEAAASTNERIAQRALEGFTRSLGKELRRGATTALVYLSPDAKPAATGLESTMRFLLSAKSAYVDGQVFSVGADDSTPPADWEKPLDGKVAIVTGAARGIGATIAEVFARDGAHVVAIDVESAAENLAETASKVGGTALWLDVTADDAVDKISEHLRDHHGGKADILVNNAGITRDKLLANMDDARWDAVLAVNLLAPLRLTEGLVGNGSIGEGGRVIGLSSIAGIAGNRGQTNYATTKAGMIGITQALAPGLAAKGITINAVAPGFIETQMTAAIPLATREVGRRLNSLLQGGQPVDVAEAIAYFASPASNAVTGNVIRVCGQAMIGA
Mass: 46,830 Da
Length: 454 Aa

Rv0242c doesn't seem to be a targeted by any drug.

Biotin metabolism mtu00780
mtu00780
Metabolism; Metabolism of cofactors and vitamins

Fatty acid biosynthesis mtu00061
mtu00061
PATHWAY_MAP mtu00061 Fatty acid biosynthesis

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.