Gene - combatTB X

Rv0248c

Type: protein_coding
Name: Rv0248c
Locus Name: Rv0248c
Product: Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Functional Category: Intermediary metabolism and respiration
Location: 298863..300803 (- strand)
Gene Length: 1940 bp
Nucleotides: ATGGTTGAGGTCGAGCGGCACTCCTACGACGTAGTCGTGATCGGTGCCGGCGGCGCGGGGTTACGCGCGGTCATCGAGGCGCGGGAACGCGGCTTGAAAGTAGCCGTCGTGTGCAAATCCCTATTCGGCAAGGCCCACACGGTCATGGCCGAAGGCGGCTGCGCGGCCGCGATGGGCAACGCCAACCCGAAGGACAATTGGAAGACTCACTTCGGCGACACGATGCGCGGTGGAAAGTTCCTGAACAACTGGCGTATGGCCGAGCTGCACGCCAAGGAGGCGCCGGACCGGGTCTGGGAGTTGGAGACCTACGGCGCGCTGTTCGACCGCACCGACGATGGCCGAATCAGTCAGCGCAACTTCGGCGGACACACCTATCCGCGACTGGCGCACGTCGGCGACCGCACCGGCCTGGAGTTGATCCGCACCCTGCAGCAAAAGGTTGTCTCGCTGCAGCAGGAGGACCACGCCGAGCTCGGCGACTACGAAGCGCGGATCAAAGTGTTCGCCGAATGCACCATCACCGAACTGCTCAAGGACCAAGGCGCGATCGCCGGAGCCTTCGGCTACTGGCGGGAAAGCGGCCGGTTCATCGTGTTCGAGGCGCCAGCGGTGGTGCTTGCCACTGGCGGGATCGGCAAGTCGTTCAAGGTGACATCCAACTCCTGGGAGTACACCGGAGACGGGCACGCGTTGGCACTGCGGGCCGGGGCGACGCTGATCAACATGGAGTTCGTCCAGTTCCACCCGACGGGCATGGTGTGGCCGCCCAGTGTCAAGGGAATTCTGGTCACTGAGGGTGTTCGCGGCGACGGCGGAGTGCTCAAAAACTCGGAGAACTCTCGCTTCATGTTCGACTACATTCCGCCGGTGTTCAAGGGCCAGTACGCCGAGACGGAGGAAGAGGCCGACCAGTGGCTTAAGGACAACGACTCGGCCCGACGCACCCCGGACTTGCTGCCCCGCGACGAGGTCGCGCGCGCGATCAACTCAGAGGTCAAGGCCGGCCGCGGTACCCCGCACGGCGGCGTCTACCTCGACATCGCATCCCGGCTGACACCCGCCGAGATCAAACGGCGATTGCCGTCGATGTATCACCAGTTCAAAGAGCTCGCTGAAGTCGATATCACAACGCAGGCAATGGAAGTCGGGCCGACGTGTCACTACGTGATGGGCGGTGTCGAAGTAGACGCGGACACCGGCGCCGCCACGGTGCCAGGCCTGTTCGCTGCCGGTGAGTGTGCCGGCGGTATGCACGGCTCCAACCGGCTGGGCGGCAATTCGCTGTCCGATCTGCTGGTATTCGGCCGGCGGGCCGGCCTGGGCGCAGCGGATTACGTACGGGCACTGAGCAGCCGGCCAGCGGTTTCAGCGGAGGCTATCGATGCGGCGGCCCAGCAGGCGCTGAGCCCCTTCGAAGGACCGAAAGACGGCTCGGCGCCGGAGAATCCGTACGCGCTGCATATGGACTTGCAGTACGTGATGAACGATCTGGTCGGTATCATCCGCAACGCCGACGAAATATCCAGGGCGCTGACTCTTTTGGCCGAGCTGTGGTCGCGCTACCACAACGTACTCGTCGAAGGTCACCGTCAATACAATCCGGGCTGGAACCTGTCCATCGACCTGCGCAACATGTTGCTGGTCAGCGAGTGCGTGGCCAGAGCTGCGCTACAGCGCACCGAAAGCCGAGGCGGCCACACCCGAGACGACCATCCCGGTATGGACCCCAACTGGCGCAGGATCTTGCTGGTATGCCGGGCCACCGAAACCATGGGCACCGGTGGCAGCGGGTCCGGCGACTCCAACTGCCACATCAACGTCACCCAGCAGCTGCAAACGCCCATGCGACCCGACTTGCTGGAGCTCTTCGAGATCTCGGAGTTGGAGAAATACTACACCGACGAAGAGCTGGCCGAGCATCCAGGACGGAGAGGCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

anaerobic respiration GO:0009061 biological_process
electron transfer activity GO:0009055 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
flavin adenine dinucleotide binding GO:0050660 molecular_function
succinate dehydrogenase activity GO:0000104 molecular_function

InterPro

UniProt: O53670
GenBank: Rv0248c
EnsemblBacteria: Rv0248c
Mycobrowser: Rv0248c

Summary

Name: Probable succinate dehydrogenase [iron-sulfur subunit] (Succinic dehydrogenase)
Family: Unknown
Protein Sequence: MVEVERHSYDVVVIGAGGAGLRAVIEARERGLKVAVVCKSLFGKAHTVMAEGGCAAAMGNANPKDNWKTHFGDTMRGGKFLNNWRMAELHAKEAPDRVWELETYGALFDRTDDGRISQRNFGGHTYPRLAHVGDRTGLELIRTLQQKVVSLQQEDHAELGDYEARIKVFAECTITELLKDQGAIAGAFGYWRESGRFIVFEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALRAGATLINMEFVQFHPTGMVWPPSVKGILVTEGVRGDGGVLKNSENSRFMFDYIPPVFKGQYAETEEEADQWLKDNDSARRTPDLLPRDEVARAINSEVKAGRGTPHGGVYLDIASRLTPAEIKRRLPSMYHQFKELAEVDITTQAMEVGPTCHYVMGGVEVDADTGAATVPGLFAAGECAGGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRALSSRPAVSAEAIDAAAQQALSPFEGPKDGSAPENPYALHMDLQYVMNDLVGIIRNADEISRALTLLAELWSRYHNVLVEGHRQYNPGWNLSIDLRNMLLVSECVARAALQRTESRGGHTRDDHPGMDPNWRRILLVCRATETMGTGGSGSGDSNCHINVTQQLQTPMRPDLLELFEISELEKYYTDEELAEHPGRRG
Mass: 70,681 Da
Length: 646 Aa

Rv0248c doesn't seem to be a targeted by any drug.

Butanoate metabolism mtu00650
mtu00650
PATHWAY_MAP mtu00650 Butanoate metabolism

Oxidative phosphorylation mtu00190
mtu00190
PATHWAY_MAP mtu00190 Oxidative phosphorylation

Citrate cycle (TCA cycle) mtu00020
mtu00020
Metabolism; Carbohydrate metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.