Gene - combatTB X

PPE2

Type: protein_coding
Name: PPE2
Locus Name: Rv0256c
Product: PPE family protein PPE2
Functional Category: Pe/ppe
Location: 307877..309547 (- strand)
Gene Length: 1670 bp
Nucleotides: ATGACCGCCCCGATCTGGATGGCTTCGCCCCCAGAGGTGCACTCGGCGCTGCTAAGCAGCGGGCCTGGGCCCGGTCCGCTGCTGGTGTCGGCCGAGGGGTGGCACTCGTTGAGCATCGCCTACGCGGAGACGGCCGACGAGCTGGCCGCGCTGTTGGCCGCCGTACAGGCCGGCACCTGGGACGGCCCGACCGCCGCGGTTTACGTGGCCGCCCATACCCCTTATCTGGCGTGGCTGGTGCAGGCCAGCGCTAACAGCGCGGCCATGGCCACCCGGCAAGAAACCGCGGCCACCGCCTACGGCACCGCCTTGGCCGCGATGCCAACGTTGGCCGAGCTGGGCGCCAACCACGCCCTCCACGGCGTGCTGATGGCGACGAACTTCTTCGGCATCAACACCATCCCGATCGCGCTCAACGAGTCCGACTACGCGCGGATGTGGATCCAGGCCGCCACCACGATGGCCAGCTATCAAGCGGTCTCGACCGCGGCGGTGGCCGCCGCACCGCAGACCACCCCAGCCCCCCAGATCGTGAAAGCCAACGCGCCGACAGCGGCTTCCGACGAGCCGAACCAAGTCCAGGAATGGCTGCAATGGTTGCAGAAGATCGGGTATACCGACTTCTACAACAACGTTATACAACCGTTCATCAACTGGCTGACCAACCTCCCCTTTTTGCAAGCGATGTTTTCCGGATTTGATCCGTGGCTGCCCTCGCTGGGTAATCCGCTAACCTTCCTAAGCCCGGCCAACATTGCGTTCGCCCTTGGCTACCCCATGGACATCGGATCTTATGTCGCCTTCCTGTCGCAAACCTTCGCATTCATCGGGGCGGATCTGGCGGCGGCGTTCGCGTCGGGCAATCCCGCAACTATCGCTTTTACCCTGATGTTCACCACGGTCGAAGCCATTGGCACGATCATCACCGATACCATCGCGCTGGTTAAAACGCTGCTCGAGCAAACTCTTGCGTTGCTCCCGGCGGCGCTGCCCCTGCTAGCCGCCCCGCTGGCGCCGTTGACCCTTGCCCCTGCGAGTGCAGCAGGCGGCTTCGCGGGCTTGTCTGGGCTGGCGGGCCTGGTTGGCATCCCGCCATCCGCGCCGCCCGTCATCCCGCCGGTCGCGGCGATTGCCCCGAGTATCCCGACCCCCACCCCAACTCCAGCCCCAGCCCCGGCCCCCACGGCCGTGACCGCGCCGACGCCCCCGCCCGGGCCGCCACCGCCGCCGGTGACCGCCCCGCCGCCGGTGACCGGAGCCGGCATACAAAGCTTCGGGTACCTGGTGGGTGACCTGAACTCGGCGGCGCAGGCCAGGAAGGCCGTCGGCACCGGCGTTCGAAAGAAGACGCCGGAACCCGACAGCGCCGAGGCCCCAGCGGCCGCGGCGGCGCCCGAGGAACAGGTTCAACCGCAGCGGCGTCGGCGGCCAAAGATCAAACAGCTCGGCCGCGGTTACGAATACCTGGATTTAGACCCCGAAACCGGCCACGACCCGACGGGTTCGCCTCAAGGAGCGGGAACCCTGGGTTTCGCCGGAACAACCCACAAGGCCAGTCCCGGACAAGTCGCAGGACTGATCACGTTACCCAACGACGCGTTCGGCGGCAGCCCACGCACGCCAATGATGCCCGGAACCTGGGACACCGACTCAGCGACCCGGGTGGAGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WI47
GenBank: Rv0256c
EnsemblBacteria: Rv0256c
Mycobrowser: Rv0256c

Summary

Name: Uncharacterized PPE family protein PPE2
Family: Mycobacterial PPE family
Protein Sequence: MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE
Mass: 56,952 Da
Length: 556 Aa

Rv0256c doesn't seem to be a targeted by any drug.

Rv0256c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.