esxH
- Type
- protein_coding
- Name
- esxH
- Locus Name
-
Rv0288
- Product
-
Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4)
- Functional Category
-
Cell wall and cell processes
- Location
- 351848..352138 (+ strand)
- Gene Length
- 290 bp
- Nucleotides
-
TGTCGCAAATCATGTACAACTACCCCGCGATGTTGGGTCACGCCGGGGATATGGCCGGATATGCCGGCACGCTGCAGAGCTTGGGTGCCGAGATCGCCGTGGAGCAGGCCGCGTTGCAGAGTGCGTGGCAGGGCGATACCGGGATCACGTATCAGGCGTGGCAGGCACAGTGGAACCAGGCCATGGAAGATTTGGTGCGGGCCTATCATGCGATGTCCAGCACCCATGAAGCCAACACCATGGCGATGATGGCCCGCGACACGGCCGAAGCCGCCAAATGGGGCGGCTAG
- Drug Resistance
- Mutations
- Function
- EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. {ECO:0000269|PubMed:24204276}.
- Family
-
WXG100 family, ESAT-6 subfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- pathogenesis GO:0009405 biological_process
- extracellular region GO:0005576 cellular_component
- InterPro
2KG7
- Name
- ESAT-6-like protein EsxH (10 kDa antigen CFP7) (CFP-7) (Low molecular weight protein antigen 7) (Protein TB10.4)
- Family
- WXG100 family, ESAT-6 subfamily
- Protein Sequence
-
MSQIMYNYPAMLGHAGDMAGYAGTLQSLGAEIAVEQAALQSAWQGDTGITYQAWQAQWNQAMEDLVRAYHAMSSTHEANTMAMMARDTAEAAKWGG
- Mass
- 10,391 Da
- Length
- 96 Aa
Summary
Rv0288 doesn't seem to be a targeted by any drug.
Rv0288 doesn't seem to be involved in any pathway.
- Solution structure of the Mycobacterium tuberculosis EsxG.EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes.
- J Biol Chem. 2011 Aug 26;286(34):29993-30002. doi: 10.1074/jbc.M111.248732. Epub 2011 Jul 5.
- A novel vaccine p846 encoding Rv3615c, Mtb10.4, and Rv2660c elicits robust immune response and alleviates lung injury induced by Mycobacterium infection.
- Hum Vaccin Immunother. 2014;10(2):378-90. doi: 10.4161/hv.27121. Epub 2013 Nov 26.
- Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
- PLoS Pathog. 2013 Oct;9(10):e1003734. doi: 10.1371/journal.ppat.1003734. Epub 2013 Oct 31.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Stoichiometric protein complex formation and over-expression using the prokaryotic native operon structure.
- FEBS Lett. 2010 Feb 19;584(4):669-74. doi: 10.1016/j.febslet.2009.12.057. Epub 2010 Jan 18.
- Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.
- J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.
- Systematic genetic nomenclature for type VII secretion systems.
- PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
- Molecular features governing the stability and specificity of functional complex formation by Mycobacterium tuberculosis CFP-10/ESAT-6 family proteins.
- J Biol Chem. 2008 Jun 20;283(25):17681-90. doi: 10.1074/jbc.M800123200. Epub 2008 Apr 21.
- High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.
- Infect Immun. 2006 Jun;74(6):3396-407. doi: 10.1128/IAI.02086-05.
- Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility.
- FEMS Microbiol Lett. 2004 Sep 1;238(1):255-62. doi: 10.1016/j.femsle.2004.07.043.
- Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family.
- Infect Immun. 2002 Oct;70(10):5446-53. doi: 10.1128/iai.70.10.5446-5453.2002.
- Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens.
- Infect Immun. 2000 Jan;68(1):214-20. doi: 10.1128/iai.68.1.214-220.2000.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.