Function

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. {ECO:0000255|HAMAP-Rule:MF_01151}.

Family

GrpE family

GO

• adenyl-nucleotide exchange factor activity GO:0000774 molecular_function
• cellular response to starvation GO:0009267 biological_process
• cell wall GO:0005618 cellular_component
• protein homodimerization activity GO:0042803 molecular_function
• unfolded protein binding GO:0051082 molecular_function
• chaperone binding GO:0051087 molecular_function
• protein folding GO:0006457 biological_process
• cytoplasm GO:0005737 cellular_component

InterPro

• IPR000740
• IPR013805
• IPR009012

UniProt

P9WMT5

GenBank

Rv0351

EnsemblBacteria

Rv0351

Mycobrowser

Rv0351

Rv0351 doesn't seem to be a targeted by any drug.

Rv0351 doesn't seem to be involved in any pathway.