Gene - combatTB X

Rv0386

Type: protein_coding
Name: Rv0386
Locus Name: Rv0386
Product: Probable transcriptional regulatory protein (probably LuxR/UhpA-family)
Functional Category: Regulatory proteins
Location: 463411..466668 (+ strand)
Gene Length: 3257 bp
Nucleotides: TGAGCAAGTTGCTGCCACGGGGCACAGTGACATTGCTGTTGGCCGACGTCGAGGGATCCACCTGGCTGTGGGAGACCCATCCAGACGACATGGGTGCTGCCGTGGCGCGCCTCGACAAAGCCGTGTCTGGTGTGATTGCCGCCCATGACGGCGTACGCCCAGTCGAGCAGGGTGAGGGTGATAGCTTTGTCCTCGCGTTCGCCTGCGCGTCGGATGCCGTGGCCGCCGCGTTGGACTTGCAGCGAGCGCGGCTCGCACCGATCCGGTTGCGCATAGGCGTGCACACCGGGGAGGTCGCGCTCCGCGACGAAGGCAACTATGCCGGTCCGACCATCAACCGGACCGCGCGCCTGCGTGACTTGGCGCATGGGGGCCAGACGGTGCTCTCGGGCGTGACCGAAAGCCTGGTCATCGATCGCCTCCCGGACAAAGCATGGCTGGTTGACCTGGGGACGCACGCGCTGCGGGATCTGTCGCGTCCGGAGCGGGTAATGCAGCTGTGTCATCCCGAATTGCGTATCGATTTCCCGCCGCTGCGGGTGGCCAATGACGATGTGGCCCATGGTCTTCCGGTGCACCTGACGCGTTTTGTGGGGCGCGGCGCGCAGATCACCGAGGTGCACCGGTTGGTGACCGATAACCGGTTGGTGACCCTGACCGGCGCCGGCGGCGTGGGCAAGACACGGCTGGCGGCGCAGCTCGCGGCGCAGATCGCCGGTGAGTTCGGTCGCGCGTGGTTCGTGGATCTGGCGCCGATCACGGACCCCGACTTGGTGCCGGTCACGGTGGCGGGCGCGCTGGGACTGCACGACCAGCCGGGCCGCTCCACGACGGACACCGTGCTGCGCTTTCTTGGCGGGCGTCCAGCCCTGGTGGTGCTGGATAACTGCGAGCACCTGCTGGATGCGACGGCGGCCTTGGTGTTAGCGCTGGTGAAAGCGTGCCGGGGGGTGAGGTTGCTGGCAACTTGTCGTGAGCCGCTCCGGGTCGAGGGTGAGGTGAGCTACCGGGTGCCGTCGCTGTCACTGAGCGATGAAGCCGTTGAGATGTTTTGCTACCGGGCTCAGCGAGTCCGGCCGGACTTTCGCCTCACCGACGACAACTCCGCCGCAGTGACCGAGATCTGCAAACGGCTGGACGGTTTGCCGCTGGCGATCGAGCTGGCGGCTGCGCGGCTGCGGTCGATGACGCTTGACGAGATCATCGATGGCTTGCGTGACCGGTTCGCGCTGTTGACCGGCGGTGCGCGCACGGCCGCGCACCGGCAGCAGACGCTGTGGGCCTCGGTGGATTGGTCGTACACGCTATTGACCGAGCCGGAACGTACCTTGTTTCGCCGGCTTGCGGTGTTTGTGGGTTGCTTTTTTGTCGACGACGCACAGGCGGTTGCCTGCAGCGGCGATGTGCAGCGCTACCAGGTCCTTGACGAGATCACCCTGCTGGTCGACAAGTCACTGGTGATGGCCGACGACAACAGCGGCCGGACGTGCTATCGGTTATGCGAGACGATGCGCCACTACGCGTTGGAAAAACTCTCCGAGGCTGGCGAGGTGGACGCCGTGTTTGCGCGGCACCGTGACTACTACACGGCGCTGGCTGCCAGGGTCGACAATCCCGGACCCTCCGATTATTCGCACTGCCTCGACCAAGCCGAAACCGAGATCGACAACCTACGTGCCGCCTTTGTGTGGAACCGGGAAAATTCCGACACCGAGGGCGCCTTGGCGCTGGCGTCCTCCCTGTTGCGGGTATGGATGACGCGGGGGCGCATCCAGGAGGGGCGCGCCTGGTTTGACAGCATTCTTGCCGACGAGAATGCGCGTCATCTCGAGGTGGCGGCCGCGGTGCGCGCCCGGGCATTGGCCGACAAGGCCCTGCTCGACATCTTCGTCGACGCCGCCGCCGGTATGGAGCAGGCCCAACAGGCTTTGGTGATCGCGCGCGAGGTCGATGAACCGGCGCTGCTGTCCCGGGCGCTCACGGCCTGCGGCTTGATCGCGGTAGCGGTAGCTCGCGCCGATGCGGCCGCGTCTTATTTCGCCGAGGCGATCGACCTGGCACGAGCGGTAGACGACCGGTGGAGGCTGGCCCAGATCCTTACCTTTCAGGCGGTCGATGCGGTCGTGGCGGGTGACCCGGTCGCGGCACGCCCGGCCGCCCAAGAGGCACGCGAGCTGGCTGCCGCGATCGGTGACCACTCCAATGCGCTGTGGTGCCGCTGGTGTCTCGGCTACGCCCAGCTGATGCGGGGGGAGCTGGCCGCGGCCGCCGCCCAATTCGGCGAGGTGGTGGACGAGGCCGAGGCGTCTCAGGAAGTGCTGCACAAGGCCAACAGCCTGCAGGGCCTGGCCTTCGCGCTCGCCTACCAGGGTGAATTGAGTGCGGCTAGGGCGGCGGCCGACGCCGCTCTCGAGGCCGCCGAGCTGGGCGAGTACTTCGCGGGTATGGGCTACTCGGCGTTGACCACGGCCGCGTTGGCCGCCGGCGACGTGCAGACGGCTCAACATGCCAGCGAGGCGGCCTGGCGGAACTTGAGTTTGGCGCTGCCCCTCTCGGCAGCGGTGCAGCGCGCGTTCAATGCCCAGGCTGCACTGGCTGGTGGTGACCTTAGCGCAGCGCGTCGTTGGTGTGACGATGCCGTGCAGTCAATGACCGGCCATCATCTGGCGATGGCGCTGGCGACTCGCGCCAGGATCGCGGTCGCCGAGGGCAAGCGGGAAGAAGCCGAACGCGACGCGCATAAGGCGCTCGCGTGCGCGGCCGAGAGCGGGGCACACCTGGATCTCCCCGACGTGCTCGAATGCCTTGCCGGCCTGGCCAGCGACGCCGGCACCCACCATGCGGCGGCACGACTCTTCGGCGCCGCCGAGGCTATCCGACAGCAGATCGGCTCGGTCCGCTTCGCGATTTACCGTTCGGACTATGTGCAGTCGGTGACGGCTCTGCGAGATGCGATGGGGGAGAAAGACTTCGACGCTGCATGGGCCGAAGGTGCCGCGTTGTCGATCAAGGAGACGATCGCCTATGCGCAACGTGGCCACTCCTGGCGCAAACGACCGGCCACCGGTTGGGAATCGCTTACTCCGACCGAGATTGACGTCGTGCGACTGGTTGGCGAGGGACTGGCCAACAAGGACATCGCGACGCGGCTTTTCGTCTCACCGCGAACAGTGCAAACGCACCTGACGCACGTCTACACCAAACTCGGCTTCACCTCGCGACTGCAACTCGCTCAAGCGGCCGCCCGCCGTACCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

pathogenesis GO:0009405 biological_process
manganese ion binding GO:0030145 molecular_function
cell wall GO:0005618 cellular_component
DNA binding GO:0003677 molecular_function
regulation of transcription, DNA-templated GO:0006355 biological_process
plasma membrane GO:0005886 cellular_component
intracellular signal transduction GO:0035556 biological_process
cAMP biosynthetic process GO:0006171 biological_process
ADP binding GO:0043531 molecular_function
guanylate cyclase activity GO:0004383 molecular_function
adenylate cyclase activity GO:0004016 molecular_function

InterPro

UniProt: O53720
GenBank: Rv0386
EnsemblBacteria: Rv0386
Mycobrowser: Rv0386

Summary

Name: Probable transcriptional regulatory protein (Probably LuxR/UhpA-family)
Family: Unknown
Protein Sequence: MSKLLPRGTVTLLLADVEGSTWLWETHPDDMGAAVARLDKAVSGVIAAHDGVRPVEQGEGDSFVLAFACASDAVAAALDLQRARLAPIRLRIGVHTGEVALRDEGNYAGPTINRTARLRDLAHGGQTVLSGVTESLVIDRLPDKAWLVDLGTHALRDLSRPERVMQLCHPELRIDFPPLRVANDDVAHGLPVHLTRFVGRGAQITEVHRLVTDNRLVTLTGAGGVGKTRLAAQLAAQIAGEFGRAWFVDLAPITDPDLVPVTVAGALGLHDQPGRSTTDTVLRFLGGRPALVVLDNCEHLLDATAALVLALVKACRGVRLLATCREPLRVEGEVSYRVPSLSLSDEAVEMFCYRAQRVRPDFRLTDDNSAAVTEICKRLDGLPLAIELAAARLRSMTLDEIIDGLRDRFALLTGGARTAAHRQQTLWASVDWSYTLLTEPERTLFRRLAVFVGCFFVDDAQAVACSGDVQRYQVLDEITLLVDKSLVMADDNSGRTCYRLCETMRHYALEKLSEAGEVDAVFARHRDYYTALAARVDNPGPSDYSHCLDQAETEIDNLRAAFVWNRENSDTEGALALASSLLRVWMTRGRIQEGRAWFDSILADENARHLEVAAAVRARALADKALLDIFVDAAAGMEQAQQALVIAREVDEPALLSRALTACGLIAVAVARADAAASYFAEAIDLARAVDDRWRLAQILTFQAVDAVVAGDPVAARPAAQEARELAAAIGDHSNALWCRWCLGYAQLMRGELAAAAAQFGEVVDEAEASQEVLHKANSLQGLAFALAYQGELSAARAAADAALEAAELGEYFAGMGYSALTTAALAAGDVQTAQHASEAAWRNLSLALPLSAAVQRAFNAQAALAGGDLSAARRWCDDAVQSMTGHHLAMALATRARIAVAEGKREEAERDAHKALACAAESGAHLDLPDVLECLAGLASDAGTHHAAARLFGAAEAIRQQIGSVRFAIYRSDYVQSVTALRDAMGEKDFDAAWAEGAALSIKETIAYAQRGHSWRKRPATGWESLTPTEIDVVRLVGEGLANKDIATRLFVSPRTVQTHLTHVYTKLGFTSRLQLAQAAARRT
Mass: 116,792 Da
Length: 1085 Aa

Rv0386 doesn't seem to be a targeted by any drug.

Rv0386 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.