Gene - combatTB X

mmpL1

Type: protein_coding
Name: mmpL1
Locus Name: Rv0402c
Product: Probable conserved transmembrane transport protein MmpL1
Functional Category: Cell wall and cell processes
Location: 480355..483231 (- strand)
Gene Length: 2876 bp
Nucleotides: GTGAGGAGCCAACGTCTAGCCGGGCACCTGTCGGCCGCCGCCCGGACGATCCATGCGTTGTCGCTACCCATCATTCTGTTCTGGGTGGCGCTGACTATTGTGGTGAACGTCGTTGCGCCGCAGCTACAGTCGGTCGCTAGGACACATTCGGTGGCGTTAGGCCCCCACGATGCTCCGTCACTGATCGCCATGAAGCGCATCGGCAAGGACTTTCAGCAATTCGATTCTGACACCACTGCAATGGTGCTGCTGGAGGGCCAAGAGAAGCTGGGTGATGAGGCGCACCGCTTCTATGACGTGCTAGTGACCAAGCTGTCACAAGACACCACCCACGTCCAACACATTGAGAACTTCTGGGGCGATCCGCTGACCGCGGCGGGATCGCAGAGCGCTGACGGCAAGGCAGCATATGTCCAGCTGAACCTCACTGGTGATCAGGGCGGCTCGCAGGCCAACGAGTCTGTCGCCGCCGTGCAACGCATCGTGGACAGCGTGCCACCGCCGCCGGGGATCAAGGCTTACGTGACAGGCCCGGGTCCACTCGGCGCCGATCGAGTTGTATACGGCGACCGCAGCCTTCACACGATTACCGGCATCAGCATTGCGGTGATCGCGATCATGTTGTTCATCGCCTACCGCTCGCTTTCTGCTGCTCTGATCATGCTGCTGACGGTCGGGCTCGAGCTGCTGGCGGTCCGCGGCATCATCTCCACTTTTGCCGTCAACGACCTCATGGGCCTGTCTACATTCACTGTCAACGTGTTGGTGGCGCTCACGATCGCGGCTTCGACGGACTACATCATCTTTCTCGTCGGACGCTATCAAGAGGCACGTGCGACTGGCCAGAACCGAGAAGCCGCTTACTACACCATGTTTGGTGGGACGGCACACGTGGTCCTGGCATCTGGCCTCACCGTCGCCGGCGCCATGTACTGCCTCGGCTTTACCCGGCTACCCTACTTCAATACCCTCGCATCGCCATGCGCGATCGGTTTGGTCACGGTGATGTTGGCGTCTCTGACGCTGGCGCCCGCGATCATCGCCGTTGCCAGCCGATTCGGGCTATTCGACCCCAAACGAGCGACAACGAAACGGCGTTGGCGCCGGATCGGCACGGTCGTCGTGCGATGGCCCGGCCCCGTCTTGGCCGCCACCCTGCTGATAGCGCTGATCGGACTGCTCGCCTTGCCGAAATACCAGACCAACTACAACGAGCGCTACTACATCCCCAGCGCGGCGCCATCCAACATCGGTTACCTCGCATCAGACCGTCACTTTCCGCAAGCCCGCATGGAACCGGAGGTCCTGATGGTCGAGGCCGATCACGACCTGCGTAACCCGACCGACATGCTCATCCTGGACAGGATCGCCAAAACCGTCTTCCATACGCCGGGGATCGCGCGGGTGCAAAGCATTACCAGACCGTTGGGGGCTCCGATCGACCACTCGTCGATCCCGTTTCAGCTCGGCATGCAAAGCACGATGACCATCGAAAACCTGCAGAACCTCAAGGACCGCGTGGCTGATCTATCCACCCTTACCGATCAACTGCAACGCATGATCGACATCACCCAGCGAACCCAGGAGCTGACGCGACAGCTAACCGATGCCACCCATGATATGAACGCTCATACCAGGCAGATGCGAGACAACGCCAACGAACTACGCGATCGAATCGCCGATTTCGACGACTTCTGGCGCCCCCTCAGAAGTTTCACGTACTGGGAGCGCCACTGCTTCGACATTCCCATCTGCTGGTCGATGCGCTCCTTGTTGAACAGCATGGATAACGTCGACAAGCTCACCGAGGACCTTGCCAACCTCACCGACGACACCGAACGCATGGACACCACACAGCGGCAACTACTCGCCCAACTGGACCCCACGATCGCCACCATGCAAACCGTCAAAGACCTTGCCCAAACACTGACCAGCGCGTTCTCCGGACTGGTCACTCAAATGGAAGACATGACCCGCAACGCCACCGTCATGGGTCGAACATTCGACGCCGCCAACAACGACGACTCGTTCTACCTTCCACCGGAGGCCTTCCAAAACCCCGACTTCCAGCGGGGTCTGAAACTCTTCCTATCCCCCGATGGCACCTGCGCTCGATTCGTCATCACCCATCGGGGTGATCCCGCGAGCGCTGAAGGCATCTCACACATCGACCCCATCATGCAGGCCGCCGACGAAGCCGTGAAAGGAACCCCGCTACAGGCTGCCAGCATCTATCTGGCGGGCACCTCATCCACCTACAAAGACATCCACGAGGGCACCCTGTATGACGTCATGATCGCCGTCGTGGCGTCGCTTTGCCTGATCTTCATCATCATGCTCGGCATCACCAGAAGCGTGGTCGCATCCGCCGTCATCGTCGGCACGGTCGCCCTTTCGCTGGGCTCAGCCTTCGGATTGTCGGTCCTCATCTGGCAGCACATCCTGCATATGCCACTGCACTGGCTCGTGCTGCCCATGGCCATCATTGTCATGTTGGCCGTCGGATCCGACTACAACCTGCTCTTGATAGCCCGATTCCAAGAAGAAATCGGGGCCGGCCTCAAAACCGGCATGATCCGAGCCATGGCCGGCACCGGCCGAGTGGTCACCATCGCCGGACTGGTGTTTGCCTTCACCATGGGCTCGATGGTGGCCAGCGATCTACGCGTCGTCGGCCAAATCGGCACCACGATCATGATCGGATTGCTGTTCGACACCCTCGTTGTCCGGTCTTACATGACGCCTGCGCTGGCAACTCTGCTCGGCCGCTGGTTCTGGTGGCCACGTCGGGTGGATCGGCTAGCCCGACAACCCCAGGTGCTCGGGCCTCGTCGCACCACTGCGCTCAGTGCGGAACGCGCAGCGCTGCTGCAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily

GO

cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WJV9
GenBank: Rv0402c
EnsemblBacteria: Rv0402c
Mycobrowser: Rv0402c

Summary

Name: Probable transport protein MmpL1
Family: Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily
Protein Sequence: MRSQRLAGHLSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYDVLVTKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIENLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERHCFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAANNDDSFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWWPRRVDRLARQPQVLGPRRTTALSAERAALLQ
Mass: 104,838 Da
Length: 958 Aa

Rv0402c doesn't seem to be a targeted by any drug.

Rv0402c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.