lpqL
- Type
- protein_coding
- Name
- lpqL
- Locus Name
-
Rv0418
- Product
-
Probable lipoprotein aminopeptidase LpqL
- Functional Category
-
Cell wall and cell processes
- Location
- 503496..504998 (+ strand)
- Gene Length
- 1502 bp
- Nucleotides
-
TGGTGAACAAATCCAGGATGATGCCGGCGGTGCTGGCCGTGGCTGTGGTCGTCGCATTCCTGACGACGGGCTGTATCCGGTGGTCTACGCAGTCGCGGCCCGTTGTTAACGGCCCCGCTGCCGCAGAGTTCGCCGTTGCGTTGCGCAACCGGGTGAGCACCGACGCGATGATGGCGCACCTATCGAAACTGCAGGACATCGCCAACGCCAACGACGGCACTCGCGCGGTGGGCACCCCTGGCTATCAGGCCAGCGTCGACTATGTGGTAAACACACTGCGCAACAGCGGTTTTGATGTGCAAACCCCGGAGTTCTCCGCTCGCGTGTTCAAGGCCGAAAAAGGGGTGGTGACCCTCGGCGGCAACACCGTGGAGGCGAGGGCGCTCGAGTACAGCCTCGGCACACCGCCGGACGGGGTGACGGGCCCGCTGGTGGCTGCCCCCGCCGACGACAGTCCGGGCTGCAGTCCGTCGGACTACGACAGGCTGCCGGTGTCCGGTGCGGTGGTGCTGGTAGATCGCGGCGTCTGTCCTTTTGCCCAGAAGGAAGACGCAGCCGCGCAGCGCGGTGCGGTGGCGCTGATCATTGCTGACAACATCGACGAGCAGGCGATGGGCGGCACCCTGGGGGCTAATACCGACGTCAAGATCCCGGTGGTGAGTGTCACCAAGTCGGTCGGATTCCAGCTACGCGGACAGTCTGGGCCAACCACCGTCAAGCTCACGGCGAGCACCCAAAGTTTCAAGGCCCGCAACGTCATCGCGCAGACGAAGACGGGGTCGTCGGCCAACGTGGTGATGGCAGGTGCGCATTTGGACAGCGTTCCGGAAGGACCCGGCATCAACGACAACGGCTCGGGAGTGGCTGCGGTTCTGGAAACGGCAGTGCAGCTGGGGAACTCACCGCATGTGTCCAACGCGGTACGGTTCGCCTTCTGGGGCGCCGAGGAATTCGGCCTGATTGGGTCACGAAACTACGTCGAGTCGCTGGACATCGACGCGCTCAAAGGCATCGCGCTGTATCTGAACTTCGACATGTTGGCGTCGCCGAACCCGGGTTACTTCACCTACGACGGTGACCAGTCGCTGCCGCTAGACGCCCGCGGTCAGCCGGTGGTGCCCGAAGGCTCGGCCGGTATCGAGCGCACGTTCGTCGCCTATCTGAAGATGGCCGGCAAGACCGCGCAGGACACCTCGTTCGACGGTCGGTCCGACTACGACGGCTTCACGCTGGCGGGTATCCCTTCGGGTGGCCTGTTCTCCGGCGCTGAGGTCAAGAAGTCCGCCGAGCAAGCCGAGCTCTGGGGCGGCACCGCCGACGAGCCTTTCGATCCCAACTATCACCAGAAGACAGACACCCTGGACCATATCGACCGCACCGCGCTCGGTATCAACGGCGCTGGCGTCGCGTACGCGGTGGGTTTGTATGCGCAGGACCTCGGCGGCCCCAACGGGGTTCCGGTCATGGCGGACCGCACCCGCCACCTGATTGCCAAACCGTGA
- Drug Resistance
- Mutations
- Function
- An aminopeptidase; acts on free N-terminal amino groups with a very strong preference for Leu in the first position. {ECO:0000250|UniProtKB:Q9HZQ8}.
- Family
-
Peptidase M28 family, M28A subfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- extracellular region GO:0005576 cellular_component
- plasma membrane GO:0005886 cellular_component
- aminopeptidase activity GO:0004177 molecular_function
- proteolysis GO:0006508 biological_process
- InterPro
Summary
- Name
- Probable lipoprotein aminopeptidase LpqL (EC 3.4.11.1) (Leucine aminopeptidase) (Lipoprotein LpqL)
- Family
- Peptidase M28 family, M28A subfamily
- Protein Sequence
-
MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFAVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP
- Mass
- 52,042 Da
- Length
- 500 Aa
Rv0418 doesn't seem to be a targeted by any drug.
Rv0418 doesn't seem to be involved in any pathway.
- Lipoproteins of slow-growing Mycobacteria carry three fatty acids and are N-acylated by apolipoprotein N-acyltransferase BCG_2070c.
- BMC Microbiol. 2013 Oct 5;13:223. doi: 10.1186/1471-2180-13-223.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.