Gene - combatTB X

PPE10

Type: protein_coding
Name: PPE10
Locus Name: Rv0442c
Product: PPE family protein PPE10
Functional Category: Pe/ppe
Location: 530751..532214 (- strand)
Gene Length: 1463 bp
Nucleotides: GTGACAAGCCCGCATTTTGCGTGGTTGCCGCCAGAGATCAATTCGGCACTGATGTTTGCCGGTCCCGGGTCGGGACCGCTAATTGCTGCGGCCACCGCCTGGGGCGAGCTGGCCGAAGAATTGCTCGCGTCAATAGCGTCGCTTGGCTCCGTCACATCCGAACTGACTAGTGGCGCCTGGCTGGGTCCGTCCGCGGCGGCGATGATGGCCGTCGCAACCCAGTACCTAGCCTGGCTCAGCACGGCGGCAGCGCAGGCGGAACAAGCGGCCGCACAGGCCATGGCAATAGCGACCGCGTTCGAGGCGGCGCTGGCGGCCACCGTGCAGCCGGCAGTGGTAGCGGCCAATCGTGGCCTGATGCAGCTGCTGGCAGCTACGAACTGGTTTGGGCAGAATGCTCCGGCGCTCATGGACGTCGAGGCGGCATACGAGCAAATGTGGGCATTGGACGTGGCGGCGATGGCTGGTTACCACTTCGATGCGTCTGCGGCCGTCGCACAACTGGCGCCCTGGCAGCAGGTCTTGCGGAACCTCGGCATCGACATCGGCAAGAACGGCCAGATCAATCTGGGCTTCGGCAACACCGGCAGCGGCAACATCGGCAACAACAACATCGGCAACAACAACATCGGCAGCGGCAACACCGGCACCGGCAACATCGGCAGCGGCAACACCGGCAGCGGCAACCTGGGCCTCGGCAACCTCGGCGACGGGAATATCGGCTTCGGCAACACCGGTAGCGGGAATATCGGGTTCGGGATCACCGGTGATCACCAGATGGGTTTCGGCGGCTTCAACTCGGGTAGCGGCAACATCGGCTTCGGGAACTCGGGCACCGGCAACGTCGGCTTATTCAACTCCGGCAGCGGAAACATCGGCATCGGGAATTCGGGCTCCCTGAACAGCGGCATCGGGACCTCGGGGACAATCAACGCGGGCCTCGGCAGCGCAGGCAGCCTCAACACCAGCTTCTGGAACGCGGGGATGCAAAACGCCGCCTTAGGAAGCGCGGCTGGCTCGGAGGCGGCCTTGGTCAGCTCCGCCGGCTACGCCACCGGCGGCATGAGCACGGCGGCTTTGAGTTCGGGCATCCTCGCCTCCGCCCTCGGATCAACGGGCGGTCTCCAACACGGCCTGGCGAACGTCCTCAACTCGGGCCTGACCAACACGCCCGTCGCCGCCCCGGCCAGTGCTCCTGTTGGCGGCCTGGACTCAGGCAACCCGAACCCCGGTAGCGGCAGTGCCGCGGCTGGCTCGGGCGCAAACCCGGGCCTTAGAAGCCCTGGCACCAGCTACCCGAGCTTCGTCAACTCGGGCAGCAACGACTCGGGCTTGCGGAATACCGCCGTGCGTGAGCCGAGTACCCCCGGCTCCGGCATCCCCAAGTCGAACTTCTACCCGAGCCCCGACCGCGAATCCGCCTACGCCAGCCCGCGGATCGGGCAGCCGGTCGGTTCGGAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

active evasion of host immune response GO:0042783 biological_process

InterPro

UniProt: P9WI41
GenBank: Rv0442c
EnsemblBacteria: Rv0442c
Mycobrowser: Rv0442c

Summary

Name: Uncharacterized PPE family protein PPE10
Family: Mycobacterial PPE family
Protein Sequence: MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE
Mass: 47,247 Da
Length: 487 Aa

Rv0442c doesn't seem to be a targeted by any drug.

Rv0442c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
The 65-kilodalton antigen of Mycobacterium tuberculosis.: J Bacteriol. 1987 Mar;169(3):1080-8. doi: 10.1128/jb.169.3.1080-1088.1987.