Rv0465c
- Type
- protein_coding
- Name
- Rv0465c
- Locus Name
-
Rv0465c
- Product
-
Probable transcriptional regulatory protein
- Functional Category
-
Regulatory proteins
- Location
- 554882..556306 (- strand)
- Gene Length
- 1424 bp
- Nucleotides
-
GTGTCCAAGACCTACGTCGGCTCGCGGGTCCGCCAACTGCGTAACGAGCGCGGGTTCAGCCAGGCCGCGCTGGCCCAGATGCTGGAGATCTCGCCGAGCTATCTGAACCAGATCGAACACGACGTCCGGCCGCTGACCGTGGCCGTGCTGCTGCGCATCACCGAAGTGTTCGGGGTGGACGCGACGTTCTTTGCCTCCCAGGACGACACCCGGCTGGTTGCCGAACTCAGGGAGGTGACCCTGGACCGCGATCTAGACATCGCCATCGACCCGCATGAAGTGGCCGAAATGGTCAGCGCTCATCCCGGGCTGGCCTGCGCGGTGGTCAACCTGCATCGGCGCTACCGGATCACCACCGCGCAGCTGGCCGCCGCGACCGAGGAGCGGTTCTCCGACGGCAGTGGCCGAGGGTCGATCACCATGCCGCACGAAGAGGTGCGCGACTACTTCTACCAACGCCAGAACTATCTACATGCGCTGGACACCGCGGCCGAAGACCTCACGGCCCAGATGCGGATGCACCACGGCGACCTGGCCCGCGAATTGACCCGCCGGCTCACCGAGGTGCACGGAGTACGCATCAACAAGCGCATCGACCTCGGTGACACCGTGCTGCACCGCTACGACCCCGCGACCAACACGCTGGAGATCAGCAGTCACCTCTCCCCGGGCCAGCAGGTGTTCAAGATGGCCGCCGAGTTGGCCTATCTCGAGTTCGGCGACCTCATCGACGCCATGGTCACCGACGGCAAGTTCACCAGCGCCGAGTCGCGGACGTTGGCCCGGCTGGGCCTGGCTAATTACTTCGCCGCGGCCACCGTGCTGCCCTACCGCCAGTTCCACGACGTCGCCGAGAATTTCCGCTACGACGTCGAGCGGCTGTCGGCGTTCTACTCGGTGAGCTACGAGACCATCGCCCACCGGCTGTCGACACTACAACGGCCTTCGATGCGCGGGGTCCCGTTCACCTTCGTCCGGGTGGACCGAGCGGGAAACATGTCAAAACGTCAGTCGGCCACCGGCTTTCACTTCTCCTCCAGCGGCGGCACCTGCCCGCTGTGGAACGTCTACGAAACGTTTGCCAACCCGGGGAAGATCTTGGTGCAAATCGCCCAGATGCCCGACGGCCGCAACTACCTGTGGGTGGCCCGCACCGTTGAGCTCCGGGCCGCCCGGTATGGTCAGCCCGGTAAGACCTTCGCGATCGGGCTGGGCTGCGAACTTCGCCACGCGCACCGGCTCGTCTACTCGGAAGGACTCGACTTGTCGGGTGACCCGAATACTGCGGCCACACCTATCGGCGCCGGTTGCCGCGTCTGCGAACGCGACAACTGTCCGCAACGCGCCTTCCCCGCCTTGGGGCGGGCACTGGATCTCGACGAACACCGCAGCACGGTGTCCCCGTATCTGGTGAAACAACTATG
- Drug Resistance
- Mutations
- Function
- Involved in the control of the glyoxylate cycle. RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon source. Does not regulate the expression of other genes involved in acetate metabolism. {ECO:0000269|PubMed:19767422}.
- Family
-
Short-chain fatty acyl-CoA assimilation regulator (ScfR) family
- GO
-
- DNA binding GO:0003677 molecular_function
- regulation of transcription, DNA-templated GO:0006355 biological_process
- plasma membrane GO:0005886 cellular_component
- response to hypoxia GO:0001666 biological_process
- sequence-specific DNA binding GO:0043565 molecular_function
- InterPro
Summary
- Name
- HTH-type transcriptional regulator RamB (icl1 and ramB operon repressor protein)
- Family
- Short-chain fatty acyl-CoA assimilation regulator (ScfR) family
- Protein Sequence
-
MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
- Mass
- 53,072 Da
- Length
- 474 Aa
Rv0465c doesn't seem to be a targeted by any drug.
Rv0465c doesn't seem to be involved in any pathway.
- A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis.
- PLoS One. 2012;7(8):e43651. doi: 10.1371/journal.pone.0043651. Epub 2012 Aug 16.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.
- J Bacteriol. 2009 Dec;191(23):7260-9. doi: 10.1128/JB.01009-09. Epub 2009 Sep 18.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.