fadB2
- Type
- protein_coding
- Name
- fadB2
- Locus Name
-
Rv0468
- Product
-
3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
- Functional Category
-
Lipid metabolism
- Location
- 558895..559755 (+ strand)
- Gene Length
- 860 bp
- Nucleotides
-
TGAGCGATGCGATCCAGCGGGTAGGGGTTGTCGGGGCCGGGCAGATGGGGTCCGGCATCGCCGAGGTCTCGGCTCGCGCCGGCGTCGAAGTGACGGTGTTCGAGCCGGCCGAGGCGTTGATCACCGCGGGACGCAACCGCATCGTGAAGTCGCTGGAGCGGGCCGTCAGCGCCGGCAAGGTAACCGAGCGCGAGCGTGACCGCGCCCTCGGCCTGTTGACCTTCACCACCGACCTCAACGACCTATCCGATAGGCAACTGGTGATCGAGGCCGTTGTCGAGGACGAGGCCGTCAAGTCCGAGATCTTCGCCGAGCTCGACCGGGTCGTCACCGATCCGGACGCGGTGCTGGCGTCGAATACCTCCAGCATCCCGATCATGAAGGTCGCCGCGGCCACCAAGCAGCCGCAACGGGTTCTTGGCCTGCATTTCTTCAATCCGGTCCCGGTGCTGCCGCTGGTCGAGTTGGTGCGCACGCTGGTCACCGACGAAGCCGCCGCCGCGCGCACGGAGGAGTTTGCCAGTACTGTGCTGGGCAAACAGGTCGTGCGTTGCTCCGACCGCTCCGGATTCGTGGTCAATGCGCTCCTGGTGCCGTATTTGCTGTCGGCGATTCGGATGGTCGAGGCCGGGTTTGCCACCGTCGAAGATGTCGACAAGGCCGTTGTTGCGGGGTTATCGCACCCGATGGGTCCGCTGCGGCTTTCCGATCTTGTCGGCCTAGACACCCTCAAGCTGATCGCGGACAAGATGTTCGAAGAATTCAAAGAACCGCACTACGGGCCCCCTCCGCTGTTGCTGCGTATGGTTGAGGCGGGCCAGTTGGGAAAGAAATCGGGTCGAGGTTTCTACACGTACTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the NAD-dependent oxidation of beta-hydroxybutyryl-CoA to acetoacetyl-CoA in vitro at pH 10. Also catalyzes the reverse reaction albeit in a lower pH range of 5.5-6.5. The reverse reaction is able to use NADPH as well as NADH. {ECO:0000269|PubMed:20378648}.
- Family
-
3-hydroxyacyl-CoA dehydrogenase family
- GO
-
- butyrate metabolic process GO:0019605 biological_process
- 3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 molecular_function
- 3-hydroxybutyryl-CoA dehydrogenase activity GO:0008691 molecular_function
- cell wall GO:0005618 cellular_component
- fatty acid elongation GO:0030497 biological_process
- cytosol GO:0005829 cellular_component
- response to host immune response GO:0052572 biological_process
- plasma membrane GO:0005886 cellular_component
- NAD+ binding GO:0070403 molecular_function
- fatty acid beta-oxidation GO:0006635 biological_process
- InterPro
6HRD
- Name
- 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
- Family
- 3-hydroxyacyl-CoA dehydrogenase family
- Protein Sequence
-
MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY
- Mass
- 30,728 Da
- Length
- 286 Aa
Summary
Rv0468 doesn't seem to be a targeted by any drug.
-
-
Butanoate metabolism mtu00650
mtu00650PATHWAY_MAP mtu00650 Butanoate metabolism
-
-
-
Benzoate degradation mtu00362
mtu00362PATHWAY_MAP mtu00362 Benzoate degradation
-
-
-
Phenylalanine metabolism mtu00360
mtu00360PATHWAY_MAP mtu00360 Phenylalanine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis.
- Microbiology. 2010 Jul;156(Pt 7):1975-82. doi: 10.1099/mic.0.038802-0. Epub 2010 Apr 8.
- Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes.
- J Bacteriol. 2002 Jul;184(14):4025-32. doi: 10.1128/jb.184.14.4025-4032.2002.
- The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophages.
- Mol Microbiol. 2001 Jul;41(2):423-37.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.