lprQ
- Type
- protein_coding
- Name
- lprQ
- Locus Name
-
Rv0483
- Product
-
Probable conserved lipoprotein LprQ
- Functional Category
-
Cell wall and cell processes
- Location
- 571710..573065 (+ strand)
- Gene Length
- 1355 bp
- Nucleotides
-
TGGTCATTCGTGTGCTGTTTCGCCCGGTATCTTTGATACCCGTGAATAACTCCAGCACCCCCCAGAGTCAGGGGCCGATCAGTCGGCGTCTGGCGTTGACGGCCCTTGGGTTTGGGGTGTTGGCACCGAACGTTCTGGTCGCGTGCGCCGGCAAAGTGACCAAGCTGGCCGAGAAGAGGCCGCCACCGGCGCCTCGTCTGACTTTCCGGCCTGCCGACTCTGCCGCCGACGTGGTGCCGATCGCGCCGATCAGCGTCGAGGTCGGTGACGGCTGGTTTCAGCGGGTCGCGCTGACCAATTCGGCAGGCAAGGTCGTCGCCGGGGCATACAGCCGGGATCGCACCATCTACACGATCACCGAGCCGCTGGGCTACGACACGACCTACACCTGGAGCGGTTCGGCCGTCGGCCATGACGGCAAGGCGGTTCCGGTGGCGGGCAAGTTCACCACCGTGGCACCCGTCAAGACGATCAACGCGGGATTCCAGCTCGCCGACGGCCAGACCGTCGGGATCGCGGCGCCGGTGATTATTCAGTTCGATTCACCGATCAGCGACAAGGCCGCCGTCGAGCGGGCACTAACCGTGACCACCGACCCGCCTGTCGAGGGCGGCTGGGCCTGGCTGCCCGACGAGGCGCAGGGCGCTCGCGTGCACTGGCGTCCTCGGGAGTACTACCCGGCGGGTACCACCGTCGACGTCGACGCCAAGCTGTATGGGCTGCCGTTCGGCGACGGCGCGTACGGCGCGCAGGATATGTCGTTGCACTTCCAGATCGGTCGTCGTCAGGTGGTCAAGGCCGAAGTCTCGTCGCACCGCATCCAAGTCGTCACCGATGCCGGCGTCATCATGGACTTCCCGTGCAGCTACGGCGAGGCCGACTTGGCGCGCAACGTCACCCGCAACGGCATCCACGTCGTCACCGAGAAATACTCGGACTTCTACATGTCCAACCCGGCCGCCGGTTACAGCCATATCCACGAACGTTGGGCGGTGCGGATTTCCAACAACGGCGAGTTCATCCATGCCAACCCTATGAGCGCCGGTGCCCAGGGCAACAGCAATGTCACCAACGGCTGTATCAACCTGTCGACGGAGAACGCCGAACAGTACTACCGCAGCGCGGTCTACGGTGACCCGGTTGAGGTGACCGGCAGTTCGATCCAGCTGTCCTACGCCGACGGTGACATCTGGGACTGGGCGGTGGACTGGGACACCTGGGTGTCGATGTCGGCGCTACCGCCACCGGCGGCCAAACCGGCGGCGACGCAAATCCCGGTCACCGCCCCGGTCACGCCGTCGGATGCCCCCACCCCGTCCGGCACACCCACGACTACTAACGGACCGGGTGGGTAG
- Drug Resistance
- Mutations
- Function
- Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. {ECO:0000269|PubMed:24041897}.
- Family
-
Unknown
- GO
-
- peptidoglycan L,D-transpeptidase activity GO:0071972 molecular_function
- cell wall organization GO:0071555 biological_process
- peptidoglycan-protein cross-linking GO:0018104 biological_process
- extracellular region GO:0005576 cellular_component
- regulation of cell shape GO:0008360 biological_process
- transferase activity, transferring acyl groups GO:0016746 molecular_function
- InterPro
1U8R
- Name
- L,D-transpeptidase 5 (LDT 5) (EC 2.3.2.-) (Ldt(Mt5))
- Family
- Unknown
- Protein Sequence
-
MVIRVLFRPVSLIPVNNSSTPQSQGPISRRLALTALGFGVLAPNVLVACAGKVTKLAEKRPPPAPRLTFRPADSAADVVPIAPISVEVGDGWFQRVALTNSAGKVVAGAYSRDRTIYTITEPLGYDTTYTWSGSAVGHDGKAVPVAGKFTTVAPVKTINAGFQLADGQTVGIAAPVIIQFDSPISDKAAVERALTVTTDPPVEGGWAWLPDEAQGARVHWRPREYYPAGTTVDVDAKLYGLPFGDGAYGAQDMSLHFQIGRRQVVKAEVSSHRIQVVTDAGVIMDFPCSYGEADLARNVTRNGIHVVTEKYSDFYMSNPAAGYSHIHERWAVRISNNGEFIHANPMSAGAQGNSNVTNGCINLSTENAEQYYRSAVYGDPVEVTGSSIQLSYADGDIWDWAVDWDTWVSMSALPPPAAKPAATQIPVTAPVTPSDAPTPSGTPTTTNGPGG
- Mass
- 47,891 Da
- Length
- 451 Aa
Summary
Rv0483 doesn't seem to be a targeted by any drug.
Rv0483 doesn't seem to be involved in any pathway.
- In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.
- Antimicrob Agents Chemother. 2013 Dec;57(12):5940-5. doi: 10.1128/AAC.01663-13. Epub 2013 Sep 16.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.