Rv0485
- Type
- protein_coding
- Name
- Rv0485
- Locus Name
-
Rv0485
- Product
-
Possible transcriptional regulatory protein
- Functional Category
-
Regulatory proteins
- Location
- 573984..575300 (+ strand)
- Gene Length
- 1316 bp
- Nucleotides
-
TGTACTCGACTAACCGCACCTCACAGTCACTCAGCCGCAAGCCCGGCCGCAAGCACCAGCTGCGATCGCACCGTTACGTCATGCCGCCGTCGCTGCACCTGTCCGATTCCGCGGCTGCGTCCGTCTTCCGGGCCGTGCGTTTGCGTGGTCCGGTCGGTCGGGACGTAATTGCTGGATCTACGTCGCTGAGCATCGCGACGGTGAACCGCCAGGTCATCGCACTGCTGGAAGCGGGCCTCCTGCGTGAGCGGGCGGACCTGGCGGTTTCCGGGGCTATCGGGCGCCCACGCGTGCCTGTCGAAGTAAACCACGAGCCTTTTGTCACCCTGGGCATCCACATCGGTGCCCGGACCACCAGCATCGTGGCCACCGACCTGTTCGGCCGCACGCTCGACACGGTGGAGACCCCGACCCCGCGTAACGCTGCCGGGGCCGCGCTGACCTCACTGGCCGACAGCGCTGACCGATACTTGCAGCGCTGGCGCCGGCGCCGTGCGCTGTGGGTCGGGGTGACGCTTGGTGGTGCAGTCGACAGTGCCACCGGTCATGTCGACCATCCGCGGCTCGGTTGGCGTCAGGCTCCGGTCGGACCCGTGCTGGCGGATGCCCTAGGCCTGCCCGTGTCGGTGGCGTCCCACGTCGACGCCATGGCCGGGGCCGAGCTGATGCTCGGCATGCGGCGGTTCGCACCGAGCTCGTCGACGAGCCTCTACGTCTACGCCCGCGAAACCGTAGGCTATGCGCTGATGATCGGTGGGCGGGTGCACTGCCCGGCCAGTGGTCCCGGCACCATCGCGCCCCTGCCCGTCCACTCTGAAATGCTCGGCGGTACCGGGCAGCTGGAGTCCACTGTCAGCGACGAGGCGGTTTTGGCTGCTGCCCGCCGGCTGCGGATCATCCCCGGCATCGCTTCGAGGACCCGGACCGGTGGGTCCGCTACCGCCATCACCGACTTGCTGCGAGTGGCACGAGCCGGTAATCAGCAAGCCAAGGAGCTGCTGGCGGAGCGGGCCCGCGTGCTCGGTGGGGCGGTCGCGCTGCTGCGTGACTTACTCAATCCCGACGAAGTGGTGGTGGGTGGCCAGGCGTTTACCGAATATCCCGAGGCGATGGAGCAGGTGGAGGCGGCGTTTACGGCAGGGTCGGTGCTGGCGCCGCGTGACATCCGCGTGACCGTTTTCGGCAACCGGGTGCAGGAGGCCGGGGCAGGCATCGTGTCCCTAAGCGGGCTCTATGCCGATCCATTGGGTGCCTTGCGGCGATCGGGCGCGCTGGATGCCCGGCTGCAGGACACCGCCCCGGAGGCGCTCGCGTGA
- Drug Resistance
- Mutations
- Function
- Positively regulates the expression of PE13 and PPE18. Can also regulate expression of some other genes. Plays a role in modulation of innate immune responses. {ECO:0000269|PubMed:19651861}.
- Family
-
ROK (NagC/XylR) family
- GO
-
- regulation of gene expression GO:0010468 biological_process
- pathogenesis GO:0009405 biological_process
- DNA binding GO:0003677 molecular_function
- InterPro
Summary
- Name
- Transcriptional regulator Rv0485
- Family
- ROK (NagC/XylR) family
- Protein Sequence
-
MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFRAVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQRWRRRRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAELMLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGTGQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELLAERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVTVFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA
- Mass
- 46,099 Da
- Length
- 438 Aa
Rv0485 doesn't seem to be a targeted by any drug.
Rv0485 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence.
- Infect Immun. 2009 Oct;77(10):4654-67. doi: 10.1128/IAI.01495-08. Epub 2009 Aug 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.