senX3
- Type
- protein_coding
- Name
- senX3
- Locus Name
-
Rv0490
- Product
-
Putative two component sensor histidine kinase SenX3
- Functional Category
-
Regulatory proteins
- Location
- 579349..580581 (+ strand)
- Gene Length
- 1232 bp
- Nucleotides
-
TGACTGTGTTCTCGGCGCTGTTGCTGGCCGGGGTTTTGTCCGCGCTGGCACTGGCCGTCGGTGGTGCTGTTGGAATGCGGCTGACGTCGCGGGTCGTCGAACAGCGCCAACGGGTGGCCACGGAGTGGTCGGGAATCACGGTTTCGCAGATGTTGCAATGCATTGTCACGCTGATGCCGCTGGGCGCCGCGGTGGTGGACACCCATCGCGACGTTGTCTACCTCAACGAACGGGCCAAAGAGCTAGGTCTGGTGCGCGACCGCCAGCTCGATGATCAGGCCTGGCGGGCCGCCCGGCAGGCGCTGGGTGGTGAAGACGTCGAGTTCGACCTGTCGCCGCGCAAGCGGTCGGCCACGGGTCGATCCGGGCTATCAGTGCATGGGCATGCCCGGTTGCTGAGCGAGGAAGACCGCCGGTTCGCCGTGGTGTTCGTGCACGACCAGTCGGATTATGCGCGGATGGAGGCGGCTAGGCGTGACTTCGTGGCCAACGTCAGTCACGAGCTCAAGACGCCCGTCGGTGCCATGGCTCTACTCGCCGAGGCGCTGCTGGCGTCGGCCGACGACTCCGAAACCGTTCGGCGGTTCGCCGAGAAGGTGCTCATTGAGGCCAACCGGCTCGGTGACATGGTCGCCGAGTTGATCGAGCTATCCCGGCTACAGGGCGCCGAGCGGCTACCCAATATGACCGACGTCGACGTCGATACGATTGTGTCGGAAGCGATTTCACGCCATAAGGTGGCGGCCGACAACGCCGACATCGAAGTCCGCACCGACGCGCCCAGCAATCTGCGGGTGCTGGGCGACCAAACTCTGCTGGTTACCGCACTGGCAAACCTGGTTTCCAATGCGATTGCCTATTCGCCGCGCGGGTCGCTGGTGTCGATCAGCCGTCGCCGTCGCGGTGCCAACATCGAGATCGCCGTCACCGACCGGGGCATCGGCATCGCGCCGGAAGACCAGGAGCGGGTCTTCGAACGGTTCTTCCGGGGGGACAAGGCGCGCTCGCGTGCCACCGGAGGCAGCGGACTCGGGTTGGCCATCGTCAAACACGTCGCGGCTAATCACGACGGCACCATCCGCGTGTGGAGCAAACCGGGAACCGGGTCAACGTTCACCTTGGCTCTTCCGGCGTTGATCGAGGCCTATCACGACGACGAGCGACCCGAGCAGGCGCGAGAGCCCGAACTGCGGTCAAACAGGTCACAACGAGAGGAAGAGCTGAGCCGATGA
- Drug Resistance
- Mutations
- Function
- Probably forms part of a two-component regulatory system senX3/regX3. Phosphorylates regX3 (Probable). {ECO:0000305}.
- Family
-
Unknown
- GO
-
- histidine phosphotransfer kinase activity GO:0009927 molecular_function
- protein autophosphorylation GO:0046777 biological_process
- pathogenesis GO:0009405 biological_process
- peptidyl-histidine phosphorylation GO:0018106 biological_process
- protein histidine kinase activity GO:0004673 molecular_function
- phosphorelay sensor kinase activity GO:0000155 molecular_function
- integral component of plasma membrane GO:0005887 cellular_component
- ATP binding GO:0005524 molecular_function
- extracellular region GO:0005576 cellular_component
- InterPro
Summary
- Name
- Sensor-like histidine kinase senX3 (EC 2.7.13.3)
- Family
- Unknown
- Protein Sequence
-
MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
- Mass
- 44,825 Da
- Length
- 410 Aa
Rv0490 doesn't seem to be a targeted by any drug.
-
-
Two-component system mtu02020
mtu02020Environmental Information Processing; Signal transduction
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- Identification of novel intergenic repetitive units in a mycobacterial two-component system operon.
- Mol Microbiol. 1997 Dec;26(5):991-1003.