Gene - combatTB X

galE2

Type: protein_coding
Name: galE2
Locus Name: Rv0501
Product: Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Functional Category: Intermediary metabolism and respiration
Location: 591654..592784 (+ strand)
Gene Length: 1130 bp
Nucleotides: TGAGTTCGTCGAACGGGCGCGGTGGCGCCGGAGGAGTCGGCGGCAGCAGTGAGCACCCGCAGTACCCCAAAGTTGTGCTGGTGACCGGTGCTTGCCGTTTCCTAGGCGGCTACCTGACCGCACGGCTTGCCCAGAACCCGCTGATCAACCGGGTCATCGCGGTGGACGCGATCGCGCCGAGCAAGGACATGCTGCGCCGGATGGGCCGAGCCGAATTTGTTCGCGCTGATATCCGAAACCCATTCATCGCCAAGGTGATTCGCAATGGCGAGGTGGACACGGTGGTGCACGCCGCGGCGGCCTCGTATGCGCCGCGGTCCGGCGGCAGTGCGGCATTGAAGGAACTTAACGTGATGGGCGCGATGCAACTGTTCGCCGCCTGCCAAAAGGCGCCCTCGGTCCGCCGGGTCGTGCTGAAGTCGACCTCTGAGGTTTACGGATCGAGCCCACACGATCCGGTGATGTTCACCGAGGACAGCAGCAGTCGACGTCCTTTCAGCCAAGGTTTCCCTAAGGACAGTCTCGATATCGAGGGCTACGTGCGCGCGCTGGGCCGACGCCGCCCCGATATTGCAGTGACTATCCTGCGGCTGGCCAACATGATCGGCCCGGCGATGGACACCACGCTTTCACGATATCTGGCCGGGCCGCTGGTCCCGACGATCTTCGGCCGTGATGCGCGACTGCAGTTGCTGCACGAGCAGGATGCGCTGGGTGCGTTGGAGCGCGCGGCGATGGCCGGCAAGGCCGGAACGTTCAACATCGGAGCCGACGGCATCCTCATGCTGTCGCAGGCGATCCGGCGGGCCGGGCGAATTCCGGTGCCGGTGCCAGGGTTTGGGGTATGGGCTCTGGATTCGCTGAGGCGAGCGAATCACTACACCGAGCTGAATCGTGAGCAATTCGCTTACCTGAGTTATGGCCGGGTTATGGACACCACCAGAATGCGCGTCGAACTGGGTTACCAGCCGAAGTGGACGACCGTCGAGGCGTTCGATGACTATTTTCGCGGCCGCGGCCTGACTCCCATTATTGACCCACATCGGGTACGCTCCTGGGAGGGTCGCGCCGTAGGTTTAGCGCAGCGCTGGGGTAGCCGAAATCCAATTCCATGGAGCGGACTCAGATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

NAD(P)-dependent epimerase/dehydratase family

GO

catalytic activity GO:0003824 molecular_function
extracellular region GO:0005576 cellular_component
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
coenzyme binding GO:0050662 molecular_function

InterPro

UniProt: P9WKT3
GenBank: Rv0501
EnsemblBacteria: Rv0501
Mycobrowser: Rv0501

Summary

Name: Uncharacterized protein Rv0501
Family: NAD(P)-dependent epimerase/dehydratase family
Protein Sequence: MSSSNGRGGAGGVGGSSEHPQYPKVVLVTGACRFLGGYLTARLAQNPLINRVIAVDAIAPSKDMLRRMGRAEFVRADIRNPFIAKVIRNGEVDTVVHAAAASYAPRSGGSAALKELNVMGAMQLFAACQKAPSVRRVVLKSTSEVYGSSPHDPVMFTEDSSSRRPFSQGFPKDSLDIEGYVRALGRRRPDIAVTILRLANMIGPAMDTTLSRYLAGPLVPTIFGRDARLQLLHEQDALGALERAAMAGKAGTFNIGADGILMLSQAIRRAGRIPVPVPGFGVWALDSLRRANHYTELNREQFAYLSYGRVMDTTRMRVELGYQPKWTTVEAFDDYFRGRGLTPIIDPHRVRSWEGRAVGLAQRWGSRNPIPWSGLR
Mass: 41,064 Da
Length: 376 Aa

Rv0501 doesn't seem to be a targeted by any drug.

Amino sugar and nucleotide sugar metabolism mtu00520
mtu00520
PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism

Galactose metabolism mtu00052
mtu00052
PATHWAY_MAP mtu00052 Galactose metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.