Gene - combatTB X

mmpL2

Type: protein_coding
Name: mmpL2
Locus Name: Rv0507
Product: Probable conserved transmembrane transport protein MmpL2
Functional Category: Cell wall and cell processes
Location: 597199..600105 (+ strand)
Gene Length: 2906 bp
Nucleotides: TGAGCGAAAGACACGCCGCACTGACGTCACTGCCGCCCATTCTGCCGCGGCTGATCCGCCGGTTTGCGGTGGTGATCGTCCTGCTCTGGCTGGGCTTCACCGCCTTTGTCAATCTCGCCGTACCGCAACTGGAAGTGGTCGGAAAAGCACACTCGGTATCGATGAGCCCCAGCGACGCCGCATCGATTCAGGCGATCAAGCGCGTTGGTCAGGTGTTCGGTGAGTTTGATTCCGATAACGCGGTAACGATCGTGCTGGAAGGCGACCAGCCACTCGGTGGGGACGCGCACCGGTTCTATAGCGATCTGATGCGGAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATGTTGCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACCTCGGCGCAATCCGCGGATTCATCGCCTTGCTCGCCGACCACAACATTTTCAGCCTTTCAACATTTGCGACCAACCTGCTCGTTCTCATGGCGATTGCGGCGAGCACGGACTACGCGATATTCATGCTCGGCCGTTACCACGAATCGCGCTACGCCGGCGAGGATCGGGAAACGGCCTTCTACACGATGTTTCACGGGACCGCCCACGTGATCTTGGGTTCGGGTTTGACCATTGCCGGCGCCATGTATTGCCTCAGCTTTGCCCGGCTTCCGTATTTTGAAACGCTCGGCGCGCCCATTGCTATCGGCATGCTGGTCGCGGTCTTGGCGGCGCTCACGCTCGGCCCGGCCGTACTGACCGTGGGCAGCTTCTTCAAGCTGTTCGATCCCAAGCGGCGGATGAACACTCGGCGGTGGCGCCGGGTGGGAACGGCAATTGTGCGTTGGCCGGGGCCGGTGCTCGCGGCGACATGCTTGGTCGCCTCCATTGGCTTGCTGGCCTTGCCCAGTTACCGGACAACGTATGATCTGCGCAAGTTCATGCCCGCCAGCATGCCGTCCAATGTGGGGGATGCGGCGGCTGGTCGACGCTTTTCACGGGCTCGGCTGAACCCTGAGGTGCTGTTGATCGAGACTGACCACGATATGCGTAATCCGGTGGACATGCTGGTGTTGGACAAGGTAGCCAAAAATATCTACCACAGTCCCGGTATTGAACAAGTGAAAGCGATAACCCGGCCCTTGGGAACAACCATCAAGCACACTTCGATACCGTTCATCATCAGCATGCAGGGCGTGAATAGTAGCGAGCAAATGGAATTCATGAAGGACCGAATTGATGACATACTGGTGCAGGTGGCCGCGATGAATACCTCCATCGAGACGATGCATCGCATGTATGCACTCATGGGCGAGGTCATTGACAACACCGTCGACATGGATCATCTCACGCATGATATGTCGGACATAACGGCTACGCTAAGAGATCATCTCGCGGATTTCGAGGATTTCTTCCGGCCTATTCGCAGCTACTTCTACTGGGAAAAACATTGTTTCGACGTTCCGCTCTGCTGGTCGATAAGATCGATATTCGATATGTTTGACAGTGTGGACCAGCTGAGCGAAAAGCTCGAGTACCTGGTCAAGGATATGGATATTCTGATTACACTGTTGCCGCAGATGCGCGCGCAGATGCCGCCGATGATATCTGCGATGACGACGATGCGGGACATGATGCTTATCTGGCATGGCACGCTTGGCGCGTTCTATAAGCAACAGGAGAGGAATAACAAGGACCCCGGCGCGATGGGCCGGGTTTTTGACGCCGCCCAGATCGATGATTCGTTCTATCTGCCGCAGTCGGCTTTTGAGAATCCGGATTTCAAGCGGGGGCTGAAGATGTTTTTGTCTCCGGACGGCAAGGCAGCCCGCTTTGTCATTGCTCTGGAGGGAGATCCCGCAACGCCCGAGGGCATCTCTCGGGTCGAGCCGATCAAGCGGGAGGCTAGAGAGGCCATAAAGGGAACTCCATTGCAGGGCGCTGCGATCTATCTGGGTGGCACCGCGGCGACGTTCAAGGATATTCGAGAGGGCGCCAGATACGATCTGCTGATCGCCGGAGTGGCGGCGATAAGCTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGGCCTGGGCTTGCTGTTCGACACCCTCGTCGTGCGCTCGTTCATGACACCGTCCATTGCTGCGCTGCTGGGACGCTGGTTCTGGTGGCCGCTACGGGTGCGCCCGCGCCCGGCCAGTCAGATGCTTCGGCCGTTCGCGCCGCGCCGATTGGTTCGCGCCTTGTTGCTGCCGTCCGGCCAGCACCCGTCAGCGACTGGCGCCCATGAGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily

GO

growth of symbiont in host cell GO:0044119 biological_process
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WJV7
GenBank: Rv0507
EnsemblBacteria: Rv0507
Mycobrowser: Rv0507

Summary

Name: Probable transport protein MmpL2
Family: Resistance-nodulation-cell division (RND) (TC 2.A.6) family, MmpL subfamily
Protein Sequence: MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYVVVYLVGNNETEAYDSVHAVRHMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTVGSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMRAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAISLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE
Mass: 106,202 Da
Length: 968 Aa

Rv0507 doesn't seem to be a targeted by any drug.

Rv0507 doesn't seem to be involved in any pathway.

Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.: J Biol Chem. 2014 Jun 6;289(23):16526-40. doi: 10.1074/jbc.M113.538959. Epub 2014 Apr 15.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.