Gene - combatTB X

hemB

Type: protein_coding
Name: hemB
Locus Name: Rv0512
Product: Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH)
Functional Category: Intermediary metabolism and respiration
Location: 604602..605591 (+ strand)
Gene Length: 989 bp
Nucleotides: TGAGCATGAGTTCCTATCCGCGGCAGCGACCGCGCCGGCTCCGCTCCACCGTCGCGATGCGCCGTCTGGTTGCGCAAACCTCGTTGGAGCCAAGGCATTTGGTGCTGCCGATGTTCGTTGCCGACGGCATTGACGAGCCGCGGCCGATTACCTCCATGCCGGGCGTGGTACAGCACACCCGGGATTCGCTACGTAGGGCCGCGGCAGCCGCGGTGGCCGCCGGCGTGGGTGGGCTGATGCTTTTCGGCGTGCCGCGCGACCAGGACAAGGACGGTGTCGGTTCGGCGGGCATCGACCCCGACGGGATCCTCAACGTCGCCCTTCGCGATCTGGCCAAGGACCTGGGTGAGGCCACGGTGTTGATGGCCGACACCTGTCTGGACGAGTTCACCGACCACGGGCACTGCGGTGTGCTCGATGACCGGGGCCGGGTCGATAACGACGCCACCGTGGCCCGCTATGTGGAACTGGCTGTGGCGCAAGCGGAATCGGGCGCCCACGTGGTCGGACCCAGTGGGATGATGGATGGCCAGGTAGCCGCGATCCGGGACGGTTTGGACGCCGCCGGCTACATCGATGTGGTGATCTTGGCCTACGCCGCGAAGTTTGCTTCGGCGTTCTACGGCCCGTTCCGCGAGGCGGTGAGCTCTAGCCTGTCCGGGGATCGGCGCACCTACCAGCAGGAGCCGGGCAACGCCGCCGAGGCGCTGCGTGAGATCGAGCTCGATCTCGACGAAGGCGCCGACATTGTGATGGTCAAACCCGCGATGGGCTACCTCGATGTGGTGGCGGCCGCGGCGGACGTCTCGCCGGTCCCGGTGGCCGCCTATCAGGTCTCGGGAGAGTACGCGATGATTCGTGCGGCGGCGGCCAATAATTGGATCGATGAGCGTGCCGCGGTGCTAGAGTCGCTGACCGGTATCCGGCGTGCCGGCGCCGACATCGTGCTCACCTACTGGGCGGTAGACGCGGCGGGCTGGCTTACGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). {ECO:0000250}.

Family

ALAD family

GO

cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
zinc ion binding GO:0008270 molecular_function
porphobilinogen synthase activity GO:0004655 molecular_function
protoporphyrinogen IX biosynthetic process GO:0006782 biological_process
heme biosynthetic process GO:0006783 biological_process

InterPro

UniProt: P9WMP5
GenBank: Rv0512
EnsemblBacteria: Rv0512
Mycobrowser: Rv0512

Summary

Name: Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase)
Family: ALAD family
Protein Sequence: MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIELDLDEGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWAVDAAGWLT
Mass: 34,871 Da
Length: 329 Aa

Rv0512 doesn't seem to be a targeted by any drug.

Porphyrin and chlorophyll metabolism mtu00860
mtu00860
PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.