Gene - combatTB X

hemL

Type: protein_coding
Name: hemL
Locus Name: Rv0524
Product: Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)
Functional Category: Intermediary metabolism and respiration
Location: 614835..616223 (+ strand)
Gene Length: 1388 bp
Nucleotides: TGGGCAGCACGGAACAGGCCACCTCGCGGGTAAGGGGAGCCGCGCGCACATCGGCGCAGCTGTTCGAGGCCGCATGCAGCGTCATACCCGGCGGAGTGAACTCCCCGGTGCGGGCGTTCACGGCGGTGGGCGGCACCCCGCGCTTCATTACCGAAGCCCACGGCTGCTGGTTGATTGACGCCGACGGCAACCGCTACGTAGACCTGGTCTGCTCATGGGGCCCGATGATCCTCGGTCACGCGCATCCGGCCGTCGTCGAGGCAGTGGCCAAGGCCGCAGCCCGCGGCCTGTCCTTCGGGGCCCCGACTCCCGCCGAAACCCAACTAGCCGGCGAGATCATCGGCCGGGTAGCTCCCGTCGAGCGGATACGGCTGGTGAACTCCGGCACCGAGGCCACTATGAGCGCCGTGCGGCTGGCCCGCGGATTCACCGGCCGGGCCAAGATCGTCAAGTTCTCCGGCTGCTACCACGGACACGTCGACGCATTGCTCGCCGACGCGGGTTCGGGAGTGGCCACCCTGGGCTTATGTGACGACCCCCAGCGCCCGGCTTCGCCGCGCTCGCAATCGTCACGGGGCCTGCCGTCCTCCCCCGGGGTCACTGGCGCCGCGGCAGCCGACACGATCGTGTTGCCCTACAACGACATCGATGCCGTACAGCAGACCTTCGCCCGGTTCGGCGAGCAGATCGCCGCCGTAATCACCGAGGCCAGCCCCGGCAACATGGGAGTCGTCCCGCCCGGGCCCGGCTTCAACGCGGCGCTGCGCGCGATCACCGCCGAGCACGGCGCCCTGCTCATCCTCGACGAGGTGATGACCGGGTTCCGGGTCAGCCGAAGTGGTTGGTACGGAATCGATCCGGTGCCCGCTGACCTGTTCGCCTTCGGCAAGGTGATGAGCGGCGGGATGCCCGCCGCCGCGTTCGGCGGGCGCGCCGAGGTGATGCAGCGGCTGGCGCCGCTGGGGCCGGTGTATCAGGCCGGCACGTTGTCGGGTAACCCGGTGGCGGTTGCCGCCGGGCTGGCAACGCTGCGGGCCGCCGACGACGCGGTCTACACCGCATTGGACGCCAACGCTGACCGCCTGGCCGGCCTGCTCTCCGAGGCACTGACGGATGCCGTTGTGCCACACCAGATTTCGCGGGCAGGCAATATGCTCAGTGTGTTCTTCGGCGAAACACCGGTGACCGACTTCGCGTCCGCGCGGGCCAGCCAGACCTGGCGTTATCCAGCGTTCTTTCATGCCATGCTGGACGCCGGTGTCTACCCGCCGTGCAGTGCCTTCGAGGCATGGTTCGTCTCGGCCGCTTTGGACGACGCGGCGTTCGGCCGGATCGCCAACGCGCTGCCCGCCGCGGCCCGAGCGGCGGCCCAGGAAAGGCCCGCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Class-III pyridoxal-phosphate-dependent aminotransferase family, HemL subfamily

GO

glutamate-1-semialdehyde 2,1-aminomutase activity GO:0042286 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component
pyridoxal phosphate binding GO:0030170 molecular_function
transaminase activity GO:0008483 molecular_function
protoporphyrinogen IX biosynthetic process GO:0006782 biological_process

InterPro

UniProt: P9WMN9
GenBank: Rv0524
EnsemblBacteria: Rv0524
Mycobrowser: Rv0524

Summary

Name: Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT)
Family: Class-III pyridoxal-phosphate-dependent aminotransferase family, HemL subfamily
Protein Sequence: MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGGTPRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGNPVAVAAGLATLRAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAGNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSAALDDAAFGRIANALPAAARAAAQERPA
Mass: 47,516 Da
Length: 462 Aa

Rv0524 doesn't seem to be a targeted by any drug.

Porphyrin and chlorophyll metabolism mtu00860
mtu00860
PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.