Gene - combatTB X

mgtA

Type: protein_coding
Name: mgtA
Locus Name: Rv0557
Product: Mannosyltransferase MgtA
Functional Category: Lipid metabolism
Location: 648536..649672 (+ strand)
Gene Length: 1136 bp
Nucleotides: TGTGTGGCGTGCGCGTTGCGATCGTCGCCGAGTCGTTCCTCCCGCAGGTGAACGGCGTCAGCAACTCGGTGGTCAAGGTACTCGAACATCTGCGTCGAACCGGTCATGAAGCCCTGGTGATCGCGCCCGACACGCCGCCAGGTGAAGACCGCGCCGAGCGACTTCACGACGGTGTCCGGGTGCACCGGGTGCCGTCGCGGATGTTCCCAAAGGTGACCACGTTGCCGCTCGGCGTGCCCACCTTCCGAATGCTGAGAGCGCTGCGCGGATTCGATCCGGATGTCGTGCATCTGGCGTCGCCGGCGCTGCTTGGCTACGGTGGACTCCATGCCGCTCGGCGGCTAGGGGTGCCCACGGTCGCGGTCTACCAAACCGATGTTCCGGGTTTCGCGTCCAGCTACGGCATTCCGATGACAGCACGGGCGGCGTGGGCATGGTTCCGCCACTTGCATCGCCTGGCTGACCGCACTCTGGCGCCGTCCACAGCGACAATGGAATCCCTTATTGCCCAGGGCATTCCGCGAGTACACCGGTGGGCACGCGGGGTGGACGTGCAACGTTTCGCGCCGTCGGCGCGAAACGAGGTGTTGAGGCGACGGTGGTCACCGGACGGCAAACCCATCGTCGGCTTTGTGGGTCGGCTTGCTCCGGAGAAGCATGTCGACCGGCTCACGGGTCTGGCGGCCTCCGGCGCCGTGCGGCTGGTGATCGTCGGCGACGGCATCGACCGGGCAAGATTGCAATCAGCAATGCCCACAGCGGTTTTCACCGGAGCACGGTATGGCAAAGAGCTCGCCGAGGCGTATGCCAGCATGGACGTCTTCGTACATTCCGGTGAGCACGAGACGTTCTGCCAAGTCGTGCAGGAAGCGCTGGCGTCGGGGCTACCGGTGATCGCTCCGGACGCCGGCGGACCGCGTGATCTGATAACCCCGCACCGCACCGGGCTGCTGTTGCCGGTCGGCGAGTTCGAGCACCGGCTTCCTGACGCCGTCGCCCACCTGGTGCACGAACGCCAGCGCTACGCGCTGGCCGCCCGGCGCAGTGTGCTGGGCCGCAGTTGGCCGGTGGTCTGCGATGAGCTGCTCGGCCACTACGAGGCGGTGCGAGGTCGGCGCACGACCCAGGCCGCGTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the addition of a mannose residue from GDP-D-mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-glycerol(ManGlcAGroAc2). {ECO:0000269|PubMed:19395496}.

Family

Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily

GO

phosphatidylinositol metabolic process GO:0046488 biological_process
pathogenesis GO:0009405 biological_process
glycolipid biosynthetic process GO:0009247 biological_process
phospholipid biosynthetic process GO:0008654 biological_process
mannosyltransferase activity GO:0000030 molecular_function
transferase activity, transferring hexosyl groups GO:0016758 molecular_function

InterPro

UniProt: P9WMY5
GenBank: Rv0557
EnsemblBacteria: Rv0557
Mycobrowser: Rv0557

Summary

Name: GDP-mannose-dependent alpha-mannosyltransferase (EC 2.4.1.-) (Guanosine diphosphomannose-dependent alpha-mannosyltransferase)
Family: Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily
Protein Sequence: MCGVRVAIVAESFLPQVNGVSNSVVKVLEHLRRTGHEALVIAPDTPPGEDRAERLHDGVRVHRVPSRMFPKVTTLPLGVPTFRMLRALRGFDPDVVHLASPALLGYGGLHAARRLGVPTVAVYQTDVPGFASSYGIPMTARAAWAWFRHLHRLADRTLAPSTATMESLIAQGIPRVHRWARGVDVQRFAPSARNEVLRRRWSPDGKPIVGFVGRLAPEKHVDRLTGLAASGAVRLVIVGDGIDRARLQSAMPTAVFTGARYGKELAEAYASMDVFVHSGEHETFCQVVQEALASGLPVIAPDAGGPRDLITPHRTGLLLPVGEFEHRLPDAVAHLVHERQRYALAARRSVLGRSWPVVCDELLGHYEAVRGRRTTQAA
Mass: 41,238 Da
Length: 378 Aa

Rv0557 doesn't seem to be a targeted by any drug.

Rv0557 doesn't seem to be involved in any pathway.

Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.: J Bacteriol. 2009 Jul;191(13):4465-72. doi: 10.1128/JB.01729-08. Epub 2009 Apr 24.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis.: J Biol Chem. 1999 Oct 29;274(44):31625-31. doi: 10.1074/jbc.274.44.31625.