Function

Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) involved in the NAD biosynthesis. Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. It is not able to use nicotinamide. PncB2 appears to be responsible for the increased salvage synthesis of NAD during infection of host tissues. {ECO:0000269|PubMed:18490451}.

Family

NAPRTase family

GO

• nicotinate nucleotide salvage GO:0019358 biological_process
• NAD biosynthetic process GO:0009435 biological_process
• NAD salvage GO:0034355 biological_process
• cytosol GO:0005829 cellular_component
• plasma membrane GO:0005886 cellular_component
• nicotinamide phosphoribosyltransferase activity GO:0047280 molecular_function
• response to hypoxia GO:0001666 biological_process
• response to host GO:0075136 biological_process
• nicotinate phosphoribosyltransferase activity GO:0004516 molecular_function
• nicotinate-nucleotide diphosphorylase (carboxylating) activity GO:0004514 molecular_function

InterPro

• IPR036068
• IPR006405
• IPR007229
• IPR040727
• IPR041525
• IPR013785

UniProt

P9WJI7

GenBank

Rv0573c

EnsemblBacteria

Rv0573c

Mycobrowser

Rv0573c

Rv0573c doesn't seem to be a targeted by any drug.

Rv0573c doesn't seem to be involved in any pathway.