Gene - combatTB X

Rv0574c

Type: protein_coding
Name: Rv0574c
Locus Name: Rv0574c
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 667252..668394 (- strand)
Gene Length: 1142 bp
Nucleotides: GTGGCTGGCAATCCTGATGTGGTGACGGTGCTGCTGGGCGGTGACGTCATGCTCGGCCGTGGCGTCGATCAGATCCTGCCTCATCCCGGCAAACCGCAATTGCGCGAACGGTATATGCGGGATGCGACCGGCTATGTTCGCCTGGCCGAGCGGGTGAACGGGCGCATTCCGCTCCCCGTGGATTGGCGCTGGCCCTGGGGCGAGGCGTTGGCGGTCCTTGAGAACACCGCGACCGACGTCTGTTTGATCAATCTGGAGACGACGATCACCGCCGACGGTGAATTCGCCGACCGCAAACCGGTCTGCTACCGGATGCACCCGGATAACGTGCCGGCGCTGACGGCATTGCGGCCGCACGTGTGCGCGCTGGCCAACAACCACATTCTCGATTTCGGCTACCAGGGGCTGACCGATACGGTCGCGGCTCTCGCCGGTGCGGGGATCCAGAGTGTCGGGGCGGGAGCCGATTTGCTCGCCGCTCGCCGCTCGGCGCTAGTCACGGTTGGCCATGAACGCCGGGTGATCGTCGGCTCGGTAGCGGCGGAATCCAGCGGCGTCCCCGAATCCTGGGCCGCCCGCCGCGACCGGCCCGGAGTGTGGTTGATCCGGGATCCGGCGCAACGCGACGTCGCCGACGATGTGGCGGCACAGGTGCTGGCGGACAAACGCCCCGGCGATATCGCCATAGTCTCGATGCATTGGGGATCCAATTGGGGCTATGCGACCGCACCCGGCGACGTCGCGTTCGCGCACCGACTGATCGACGCCGGCATCGACATGGTCCACGGACATTCCTCGCACCATCCGCGGCCAATCGAGATATATCGCGGTAAACCGATCCTGTACGGATGCGGTGACGTCGTTGACGACTACGAAGGCATCGGCGGGCACGAGTCGTTCCGCAGTGAACTGCGACTGCTGTATCTGACCGTCACCGATCCCGCCAGCGGGAACCTGATCTCGCTGCAGATGCTTCCACTGCGAGTGTCGCGGATGCGCCTACAGCGTGCCTCCCAGACCGACACCGAATGGCTCCGCAACACCATTGAGCGCATCAGCCGCCGGTTCGGGATTCGAGTCGTGACTCGACCCGACAACCTGCTGGAGGTCGTTCCCGCTGCCAACCTAACGAGCAAGGAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Could be involved in the biosynthesis, transport or localization of poly-alpha-L-glutamine (PLG), a cell wall component. Contributes to stress tolerance and virulence. {ECO:0000269|PubMed:25312955}.

Family

CapA family

GO

creatine metabolic process GO:0006600 biological_process
creatine biosynthetic process GO:0006601 biological_process
protein export from nucleus GO:0006611 biological_process
protein targeting to membrane GO:0006612 biological_process
ribosomal protein import into nucleus GO:0006610 biological_process
phosphoarginine metabolic process GO:0006604 biological_process
protein targeting GO:0006605 biological_process
creatinine catabolic process GO:0006602 biological_process
phosphocreatine metabolic process GO:0006603 biological_process
obsolete snRNP protein import into nucleus GO:0006608 biological_process
obsolete mRNA-binding (hnRNP) protein import into nucleus GO:0006609 biological_process
protein import into nucleus GO:0006606 biological_process
NLS-bearing protein import into nucleus GO:0006607 biological_process
2-chlorobenzoate 1,2-dioxygenase activity GO:0018626 molecular_function
naphthalene 1,2-dioxygenase activity GO:0018625 molecular_function
terephthalate 1,2-dioxygenase activity GO:0018628 molecular_function
2-aminobenzenesulfonate 2,3-dioxygenase activity GO:0018627 molecular_function
2-hydroxyquinoline 5,6-dioxygenase activity GO:0018629 molecular_function
monoacylglycerol biosynthetic process GO:0006640 biological_process
triglyceride metabolic process GO:0006641 biological_process
phospholipid metabolic process GO:0006644 biological_process
triglyceride mobilization GO:0006642 biological_process
membrane lipid metabolic process GO:0006643 biological_process
acyl-CoA metabolic process GO:0006637 biological_process
neutral lipid metabolic process GO:0006638 biological_process

InterPro

IPR019079

UniProt: P9WM79
GenBank: Rv0574c
EnsemblBacteria: Rv0574c
Mycobrowser: Rv0574c

Summary

Name: Probable polyglutamine synthesis accessory protein Rv0574c
Family: CapA family
Protein Sequence: MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE
Mass: 41,547 Da
Length: 380 Aa

Rv0574c doesn't seem to be a targeted by any drug.

Rv0574c doesn't seem to be involved in any pathway.

The conserved hypothetical protein Rv0574c is required for cell wall integrity, stress tolerance, and virulence of Mycobacterium tuberculosis.: Infect Immun. 2015 Jan;83(1):120-9. doi: 10.1128/IAI.02274-14. Epub 2014 Oct 13.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.: J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7534-9. doi: 10.1073/pnas.121172498.
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.: J Exp Med. 2003 Sep 1;198(5):705-13. doi: 10.1084/jem.20030205.
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.: Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007.