Function

Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. {ECO:0000269|PubMed:19016878, ECO:0000269|PubMed:22354968, ECO:0000269|PubMed:25622615}.

Family

PINc/VapC protein family

GO

• magnesium ion binding GO:0000287 molecular_function
• toxin-antitoxin pair type II binding GO:0097351 molecular_function
• RNA binding GO:0003723 molecular_function
• extracellular region GO:0005576 cellular_component
• negative regulation of growth GO:0045926 biological_process
• ribonuclease activity GO:0004540 molecular_function

InterPro

• IPR029060
• IPR002716
• IPR022907

UniProt

O07783

GenBank

Rv0595c

EnsemblBacteria

Rv0595c

Mycobrowser

Rv0595c

Rv0595c doesn't seem to be a targeted by any drug.

Rv0595c doesn't seem to be involved in any pathway.