Gene - combatTB X

galK

Type: protein_coding
Name: galK
Locus Name: Rv0620
Product: Probable galactokinase GalK (galactose kinase)
Functional Category: Intermediary metabolism and respiration
Location: 712716..713807 (+ strand)
Gene Length: 1091 bp
Nucleotides: TGACGGTCAGCTACGGCGCACCCGGGCGGGTCAACCTGATCGGCGAACACACCGATTACAACCTGGGTTTCGCGCTGCCGATTGCGTTGCCGCGGCGCACCGTTGTCACGTTCACCCCCGAGCACACCGGCGCGATCACCGCGCGCAGCGACCGCGCCGACGGCTCGGCGCGGATCCCGCTCGACACCACGCCGGGGCAGGTGACCGGCTGGGCAGCCTATGCGGCCGGGGCGATCTGGGCGCTGCGGGGCGCCGGCCACCCGGTGCCCGGCGGGGCGATGTCGATCACCAGCGACGTCGAGATCGGGTCGGGGCTTTCGTCGTCGGCGGCGCTGATCGGCGCGGTGCTGGGCGCGGTCGGCGCCGCCACCGGCACCCGCATCGACCGTCTCGAGCGGGCCCGGCTCGCACAGCGAGCCGAGAACGACTACGTCGGTGCCCCAACGGGTTTGCTCGACCACCTGGCCGCGCTGTTCGGAGCGCCGAAGACCGCGCTGCTGATCGACTTTCGCGACATCACCGTGCGCCCGGTGGCCTTCGACCCGGACGCCTGCGATGTGGTGCTGCTGTTGATGGATTCTCGAGCCCGACACTGTCACGCCGGCGGGGAGTATGCGCTGCGCCGGGCGTCGTGTGAACGGGCGGCCGCCGATCTGGGGGTGTCCTCGTTGCGCGCTGTGCAGGATCGCGGGCTGGCGGCGCTGGGCGCGATCGCCGATCCGATCGACGCGCGCCGCGCCCGGCACGTGCTGACCGAGAATCAGCGGGTGCTGGATTTCGCGGCCGCACTGGCTGATTCGGATTTCACCGCCGCCGGGCAGCTGCTGACCGCGTCGCATGAGTCCATGCGCGAGGACTTCGCCATCACCACCGAGCGGATCGATCTGATCGCCGAGAGCGCCGTACGGGCCGGTGCGCTGGGCGCCCGGATGACCGGGGGCGGCTTCGGGGGCGCCGTGATCGCACTGGTGCCTGCCGATAGGGCGCGCGACGTGGCCGACACGGTGCGACGGGCGGCGGTCACCGCCGGCTACGACGAGCCGGCGGTGAGCCGGACCTATGCCGCGCCCGGCGCGGCCGAGTGCCGTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). {ECO:0000255|HAMAP-Rule:MF_00246}.

Family

GHMP kinase family, GalK subfamily

GO

magnesium ion binding GO:0000287 molecular_function
ATP binding GO:0005524 molecular_function
galactose binding GO:0005534 molecular_function
cytosol GO:0005829 cellular_component
cytoplasm GO:0005737 cellular_component
galactose catabolic process via UDP-galactose GO:0033499 biological_process
galactokinase activity GO:0004335 molecular_function

InterPro

UniProt: P9WN63
GenBank: Rv0620
EnsemblBacteria: Rv0620
Mycobrowser: Rv0620

Summary

Name: Galactokinase (EC 2.7.1.6) (Galactose kinase)
Family: GHMP kinase family, GalK subfamily
Protein Sequence: MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR
Mass: 37,572 Da
Length: 363 Aa

Rv0620 doesn't seem to be a targeted by any drug.

Amino sugar and nucleotide sugar metabolism mtu00520
mtu00520
PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism

Galactose metabolism mtu00052
mtu00052
PATHWAY_MAP mtu00052 Galactose metabolism

targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.