Gene - combatTB X

Type: protein_coding
Name: nusG
Locus Name: Rv0639
Product: Probable transcription antitermination protein NusG
Functional Category: Information pathways
Location: 734254..734970 (+ strand)
Gene Length: 716 bp
Nucleotides: TGACTACCTTCGACGGTGACACGTCCGCGGGTGAGGCGGTCGATCTAACAGAGGCCAACGCCTTCCAGGATGCAGCGGCCCCGGCTGAAGAGGTCGATCCGGCCGCCGCGCTCAAAGCGGAGCTGCGCAGCAAGCCCGGCGACTGGTACGTCGTTCACTCCTACGCAGGGTACGAGAACAAGGTCAAGGCCAACCTGGAAACCCGGGTGCAGAACCTTGATGTCGGCGACTACATCTTCCAGGTGGAGGTGCCCACCGAAGAGGTCACCGAGATCAAAAACGGCCAACGCAAGCAGGTCAACCGTAAGGTGCTGCCCGGCTACATTCTGGTGCGGATGGACTTGACCGACGACTCCTGGGCCGCGGTGCGTAACACGCCGGGGGTCACGGGGTTCGTTGGGGCAACATCTCGCCCGTCAGCGCTCGCCCTCGACGACGTGGTGAAGTTTCTGCTTCCGCGGGGGTCGACGAGGAAGGCTGCCAAGGGTGCGGCCAGCACGGCTGCCGCCGCCGAGGCGGGCGGGCTAGAGCGTCCGGTCGTCGAGGTCGACTACGAGGTGGGCGAATCGGTAACCGTCATGGACGGGCCGTTTGCCACATTGCCGGCCACGATCAGCGAGGTCAACGCCGAACAGCAGAAACTCAAGGTGCTGGTCTCCATCTTCGGCCGCGAAACACCGGTGGAGCTGACCTTTGGCCAAGTCTCCAAGATCTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Participates in transcription elongation, termination and antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}.

Family

NusG family

GO

cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
DNA-templated transcription, termination GO:0006353 biological_process
DNA-templated transcription, elongation GO:0006354 biological_process
plasma membrane GO:0005886 cellular_component
regulation of DNA-templated transcription, elongation GO:0032784 biological_process
transcription antitermination GO:0031564 biological_process

InterPro

Summary

Name: Transcription termination/antitermination protein NusG
Family: NusG family
Protein Sequence: MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSKPGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKGAASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIFGRETPVELTFGQVSKI
Mass: 25,447 Da
Length: 238 Aa

Rv0639 doesn't seem to be a targeted by any drug.

Rv0639 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
A bacterial transcription terminator with inefficient molecular motor action but with a robust transcription termination function.: J Mol Biol. 2010 Feb 5;395(5):966-82. doi: 10.1016/j.jmb.2009.12.022. Epub 2009 Dec 21.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.