rplA
- Type
- protein_coding
- Name
- rplA
- Locus Name
-
Rv0641
- Product
-
50S ribosomal protein L1 RplA
- Functional Category
-
Information pathways
- Location
- 735517..736224 (+ strand)
- Gene Length
- 707 bp
- Nucleotides
-
TGAGCAAGACCAGCAAGGCATATCGCGCCGCCGCCGCGAAGGTGGACCGCACCAACCTCTACACCCCGCTGCAGGCGGCCAAGCTTGCCAAAGAGACCTCGTCGACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGATGTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGATCAGATGGCCAAAGTCGGTCGCATCGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAAACCGGCACCGTCACCGCCGACGTCGCCAAGGCCGTCGCGGACATCAAGGGCGGCAAGATCAACTTCCGGGTTGACAAGCAGGCCAACCTGCACTTCGTCATCGGGAAAGCGTCGTTCGACGAGAAGTTGTTGGCGGAGAACTACGGCGCGGCGATCGACGAGGTGCTGCGGCTCAAGCCGTCCTCGTCGAAGGGCCGCTACCTGAAGAAGATCACCGTGTCGACGACGACGGGCCCGGGCATTCCGGTCGACCCATCCATCACCCGCAACTTCGCGGGGGAGTAG
- Drug Resistance
- Mutations
- Function
- Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. {ECO:0000255|HAMAP-Rule:MF_01318}.; FUNCTION: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. {ECO:0000255|HAMAP-Rule:MF_01318}.
- Family
-
Universal ribosomal protein uL1 family
- GO
-
- cytosolic large ribosomal subunit GO:0022625 cellular_component
- structural constituent of ribosome GO:0003735 molecular_function
- RNA binding GO:0003723 molecular_function
- maturation of LSU-rRNA GO:0000470 biological_process
- rRNA binding GO:0019843 molecular_function
- cell wall GO:0005618 cellular_component
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- regulation of translation GO:0006417 biological_process
- translation GO:0006412 biological_process
- tRNA binding GO:0000049 molecular_function
- InterPro
Summary
- Name
- 50S ribosomal protein L1
- Family
- Universal ribosomal protein uL1 family
- Protein Sequence
-
MSKTSKAYRAAAAKVDRTNLYTPLQAAKLAKETSSTKQDATVEVAIRLGVDPRKADQMVRGTVNLPHGTGKTARVAVFAVGEKADAAVAAGADVVGSDDLIERIQGGWLEFDAAIATPDQMAKVGRIARVLGPRGLMPNPKTGTVTADVAKAVADIKGGKINFRVDKQANLHFVIGKASFDEKLLAENYGAAIDEVLRLKPSSSKGRYLKKITVSTTTGPGIPVDPSITRNFAGE
- Mass
- 24,756 Da
- Length
- 235 Aa
Rv0641 doesn't seem to be a targeted by any drug.
-
-
Ribosome mtu03010
mtu03010PATHWAY_MAP mtu03010 Ribosome
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.