Gene - combatTB X

end

Type: protein_coding
Name: end
Locus Name: Rv0670
Product: Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)
Functional Category: Information pathways
Location: 769792..770550 (+ strand)
Gene Length: 758 bp
Nucleotides: TGCTCATTGGTTCGCATGTCAGCCCAACCGATCCGCTGGCCGCAGCGGAGGCCGAAGGCGCTGACGTAGTGCAGATTTTCCTTGGCAATCCGCAGAGCTGGAAGGCTCCCAAGCCGCGGGACGACGCCGCCGCGCTGAAAGCCGCGACCCTGCCCATCTACGTGCATGCGCCCTACCTGATCAACCTTGCGTCGGCGAACAATCGCGTGCGGATCCCGTCGCGCAAGATCCTGCAAGAGACCTGTGCTGCGGCGGCCGACATTGGCGCAGCGGCGGTGATCGTGCACGGTGGGCACGTCGCCGACGACAACGACATCGACAAGGGCTTCCAGCGCTGGCGCAAGGCGCTGGACCGGCTGGAAACCGAGGTTCCCGTCTACCTGGAAAACACCGCCGGCGGCGATCACGCGATGGCGCGCCGCTTCGACACCATCGCCCGGCTCTGGGACGTCATCGGCGACACCGGAATCGGGTTTTGCCTGGACACCTGCCACACCTGGGCGGCCGGCGAGGCGCTGACCGATGCCGTCGATCGGATCAAAGCAATTACCGGCCGCATCGATCTGGTGCACTGCAACGACTCCAGGGACGAAGCGGGATCGGGCCGTGACCGCCACGCCAACCTCGGCAGCGGCCAGATTGATCCTGACCTGCTGGTGGCTGCCGTCAAGGCGGCCGGCGCGCCGGTGATCTGCGAAACCGCCGACCAAGGTCGCAAGGACGACATCGCGTTTCTGCGGGAAAGAACCGGCAGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. {ECO:0000255|HAMAP-Rule:MF_00152}.

Family

AP endonuclease 2 family

GO

DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 molecular_function
DNA binding GO:0003677 molecular_function
base-excision repair GO:0006284 biological_process
phosphoric diester hydrolase activity GO:0008081 molecular_function
deoxyribonuclease IV (phage-T4-induced) activity GO:0008833 molecular_function
zinc ion binding GO:0008270 molecular_function

InterPro

UniProt: P9WQ13
GenBank: Rv0670
EnsemblBacteria: Rv0670
Mycobrowser: Rv0670

Summary

Name: Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV)
Family: AP endonuclease 2 family
Protein Sequence: MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRKDDIAFLRERTGS
Mass: 26,845 Da
Length: 252 Aa

Rv0670 doesn't seem to be a targeted by any drug.

Base excision repair mtu03410
mtu03410
Genetic Information Processing; Replication and repair

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Mce2R from Mycobacterium tuberculosis represses the expression of the mce2 operon.: Tuberculosis (Edinb). 2009 Jan;89(1):22-8. doi: 10.1016/j.tube.2008.09.002. Epub 2008 Nov 22.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.