Gene - combatTB X

fusA1

Type: protein_coding
Name: fusA1
Locus Name: Rv0684
Product: Probable elongation factor G FusA1 (EF-G)
Functional Category: Information pathways
Location: 782485..784590 (+ strand)
Gene Length: 2105 bp
Nucleotides: TGGCACAGAAGGACGTGCTGACCGACCTGAGTAGGGTCCGCAACTTCGGCATCATGGCGCACATCGATGCCGGCAAGACCACAACCACCGAGCGCATCCTGTACTACACCGGTATCAACTACAAGATTGGTGAGGTGCACGACGGCGCAGCCACCATGGACTGGATGGAACAGGAACAGGAGCGCGGCATCACCATCACCTCTGCGGCCACGACCACGTTCTGGAAAGACAACCAGCTCAATATCATCGACACGCCAGGGCATGTGGATTTCACCGTCGAGGTGGAGCGCAATCTGCGCGTGCTCGACGGCGCGGTCGCGGTTTTCGACGGCAAAGAGGGTGTCGAACCGCAGTCCGAACAGGTGTGGCGGCAGGCCGACAAATACGATGTCCCCCGAATCTGCTTCGTCAACAAGATGGACAAGATCGGTGCGGACTTCTACTTCTCGGTTCGCACGATGGGGGAGCGGCTTGGGGCCAACGCCGTGCCCATTCAGCTTCCCGTCGGTGCGGAGGCCGACTTCGAAGGCGTCGTCGACCTGGTGGAGATGAACGCCAAGGTGTGGCGCGGCGAGACGAAACTCGGCGAAACCTACGACACCGTGGAAATACCGGCCGACCTGGCCGAGCAGGCTGAGGAGTACCGGACCAAGCTGCTCGAGGTGGTCGCCGAGTCCGACGAGCACCTGTTGGAGAAGTACCTGGGCGGTGAGGAGCTCACCGTCGACGAGATCAAGGGCGCGATCCGCAAGCTGACAATCGCCAGCGAGATCTACCCGGTGCTGTGCGGCAGCGCGTTCAAGAACAAGGGCGTGCAGCCGATGCTGGATGCCGTCGTCGACTACCTGCCGTCGCCGCTGGACGTTCCGCCGGCGATCGGGCACGCGCCCGCCAAGGAGGACGAGGAGGTGGTGCGCAAGGCGACCACCGACGAGCCCTTTGCGGCCCTGGCGTTCAAGATCGCTACTCACCCGTTCTTCGGCAAGCTCACCTACATCCGGGTGTACTCGGGCACCGTCGAGTCGGGTAGCCAGGTCATCAATGCCACCAAGGGCAAGAAAGAACGGCTGGGCAAGCTGTTCCAGATGCACTCCAACAAGGAGAACCCGGTCGATAGGGCTAGTGCCGGTCACATCTACGCGGTGATCGGTCTCAAGGACACCACCACCGGTGACACCTTGAGCGACCCGAACCAGCAGATCGTGCTGGAGTCGATGACCTTCCCCGACCCGGTGATCGAGGTGGCCATCGAGCCGAAGACCAAGAGCGACCAAGAGAAGCTGAGTCTGTCGATCCAGAAGCTCGCCGAAGAGGATCCGACCTTCAAGGTGCACCTGGATTCCGAGACCGGCCAGACCGTCATCGGCGGCATGGGCGAGCTGCATCTGGACATCCTGGTGGACCGCATGCGCCGGGAATTCAAGGTCGAGGCCAACGTCGGCAAGCCTCAGGTTGCCTACAAGGAGACCATCAAGCGGCTCGTGCAGAACGTCGAGTACACCCACAAGAAGCAGACGGGTGGCTCGGGCCAGTTCGCCAAGGTCATCATCAACCTCGAGCCGTTCACCGGTGAAGAGGGCGCGACCTACGAGTTCGAGAGCAAAGTCACCGGCGGGCGTATCCCGCGGGAGTACATCCCGTCGGTGGATGCCGGCGCACAGGACGCCATGCAGTACGGCGTGCTGGCCGGCTATCCGCTGGTGAACCTGAAGGTCACGCTGCTCGACGGCGCCTACCACGAGGTTGACTCCTCGGAAATGGCGTTCAAGATCGCGGGCTCGCAGGTGCTCAAAAAGGCTGCCGCACTTGCGCAGCCGGTGATCCTGGAACCGATCATGGCGGTCGAGGTGACCACACCCGAGGACTACATGGGTGACGTGATCGGCGACCTGAACTCCCGCCGTGGCCAGATCCAGGCCATGGAGGAGCGGGCTGGTGCGCGCGTTGTTAGGGCGCACGTGCCGCTGTCGGAGATGTTCGGCTACGTCGGTGACCTTCGGTCCAAGACTCAAGGCCGGGCAAACTACTCCATGGTGTTCGACTCGTACTCCGAAGTGCCGGCGAACGTGTCGAAGGAAATCATCGCGAAGGCGACGGGCGAGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). {ECO:0000250}.

Family

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily

GO

translation elongation factor activity GO:0003746 molecular_function
GTPase activity GO:0003924 molecular_function
cell wall GO:0005618 cellular_component
GTP binding GO:0005525 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component

InterPro

UniProt: P9WNM7
GenBank: Rv0684
EnsemblBacteria: Rv0684
Mycobrowser: Rv0684

Summary

Name: Elongation factor G (EF-G)
Family: TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Protein Sequence: MAQKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGEVHDGAATMDWMEQEQERGITITSAATTTFWKDNQLNIIDTPGHVDFTVEVERNLRVLDGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAVPIQLPVGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTKLLEVVAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFKNKGVQPMLDAVVDYLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALAFKIATHPFFGKLTYIRVYSGTVESGSQVINATKGKKERLGKLFQMHSNKENPVDRASAGHIYAVIGLKDTTTGDTLSDPNQQIVLESMTFPDPVIEVAIEPKTKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGMGELHLDILVDRMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVIINLEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLVNLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVTTPEDYMGDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMFGYVGDLRSKTQGRANYSMVFDSYSEVPANVSKEIIAKATGE
Mass: 77,203 Da
Length: 701 Aa

Rv0684 doesn't seem to be a targeted by any drug.

Rv0684 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .: PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.