Gene - combatTB X

tuf

Type: protein_coding
Name: tuf
Locus Name: Rv0685
Product: Probable iron-regulated elongation factor TU Tuf (EF-TU)
Functional Category: Information pathways
Location: 784821..786011 (+ strand)
Gene Length: 1190 bp
Nucleotides: TGGCGAAGGCGAAGTTCCAGCGGACCAAGCCCCACGTCAACATCGGGACCATCGGTCACGTTGACCACGGCAAGACCACCCTGACCGCGGCTATCACCAAGGTCCTGCACGACAAATTCCCCGATCTGAACGAGACGAAGGCATTCGACCAGATCGACAACGCCCCCGAGGAGCGTCAGCGCGGTATCACCATCAACATCGCGCACGTGGAGTACCAGACCGACAAGCGGCACTACGCACACGTCGACGCCCCTGGCCACGCCGACTACATCAAGAACATGATCACCGGCGCCGCGCAGATGGACGGTGCGATCCTGGTGGTCGCCGCCACCGACGGCCCGATGCCCCAGACCCGCGAGCACGTTCTGCTGGCGCGTCAAGTGGGTGTGCCCTACATCCTGGTAGCGCTGAACAAGGCCGACGCAGTGGACGACGAGGAGCTGCTCGAACTCGTCGAGATGGAGGTCCGCGAGCTGCTGGCTGCCCAGGAATTCGACGAGGACGCCCCGGTTGTGCGGGTCTCGGCGCTCAAGGCGCTCGAGGGTGACGCGAAGTGGGTTGCCTCTGTCGAGGAACTGATGAACGCGGTCGACGAGTCGATTCCGGACCCGGTCCGCGAGACCGACAAGCCGTTCCTGATGCCGGTCGAGGACGTCTTCACCATTACCGGCCGCGGAACCGTGGTCACCGGACGTGTGGAGCGCGGCGTGATCAACGTGAACGAGGAAGTTGAGATCGTCGGCATTCGCCCATCGACCACCAAGACCACCGTCACCGGTGTGGAGATGTTCCGCAAGCTGCTCGACCAGGGCCAGGCGGGCGACAACGTTGGTTTGCTGCTGCGGGGCGTCAAGCGCGAGGACGTCGAGCGTGGCCAGGTTGTCACCAAGCCCGGCACCACCACGCCGCACACCGAGTTCGAAGGCCAGGTCTACATCCTGTCCAAGGACGAGGGCGGCCGGCACACGCCGTTCTTCAACAACTACCGTCCGCAGTTCTACTTCCGCACCACCGACGTGACCGGTGTGGTGACACTGCCGGAGGGCACCGAGATGGTGATGCCCGGTGACAACACCAACATCTCGGTGAAGTTGATCCAGCCCGTCGCCATGGACGAAGGTCTGCGTTTCGCGATCCGCGAGGGTGGCCGCACCGTGGGCGCCGGCCGGGTCACCAAGATCATCAAGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00118}.

Family

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily

GO

response to iron ion GO:0010039 biological_process
translation elongation factor activity GO:0003746 molecular_function
GTPase activity GO:0003924 molecular_function
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
GTP binding GO:0005525 molecular_function
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
response to hypoxia GO:0001666 biological_process
zymogen binding GO:0035375 molecular_function
translational elongation GO:0006414 biological_process

InterPro

UniProt: P9WNN1
GenBank: Rv0685
EnsemblBacteria: Rv0685
Mycobrowser: Rv0685

Summary

Name: Elongation factor Tu (EF-Tu)
Family: TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
Protein Sequence: MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK
Mass: 43,594 Da
Length: 396 Aa

Rv0685 doesn't seem to be a targeted by any drug.

Rv0685 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Monoclonal antibodies specific for elongation factor Tu and complete nucleotide sequence of the tuf gene in Mycobacterium tuberculosis.: Infect Immun. 1992 Aug;60(8):3136-42.