pqqE
- Type
- protein_coding
- Name
- pqqE
- Locus Name
-
Rv0693
- Product
-
Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 792157..793332 (+ strand)
- Gene Length
- 1175 bp
- Nucleotides
-
TGACGAGCCCCGTACCCCGACTCATCGAGCAGTTCGAGCGGGGGCTCGACGCGCCGATCTGCCTTACCTGGGAGCTGACCTACGCCTGCAACCTAGCTTGCGTGCACTGCCTGTCGTCCTCGGGCAAACGCGATCCCGGCGAGTTGTCCACCCGCCAATGCAAGGACATCATCGACGAACTGGAACGCATGCAGGTGTTCTACGTGAACATCGGCGGCGGCGAACCAACCGTGCGCCCGGACTTTTGGGAGCTGGTAGATTACGCCACCGCACACCACGTCGGGGTGAAATTCTCCACCAACGGGGTCCGGATCACCCCCGAGGTGGCCACGCGGCTGGCAGCCACCGACTACGTCGACGTTCAGATCTCACTCGACGGCGCCACGGCCGAGGTCAACGACGCCATCCGCGGCACCGGGTCGTTCGACATGGCGGTGCGCGCGCTGCAGAACCTGGCAGCGGCGGGATTTGCCGGCGTCAAGATCTCGGTTGTGATCACCCGGCGCAACGTCGCCCAGCTCGACGAATTCGCCACGCTGGCAAGCCGTTACGGAGCGACGTTGCGGATAACCAGGTTGCGACCGTCCGGGCGCGGGACTGACGTATGGGCCGACCTGCACCCCACCGCCGACCAGCAGGTGCAGCTTTACGACTGGCTGGTTTCCAAAGGAGAGCGGGTGCTCACCGGCGATTCCTTCTTCCACCTGGCGCCGCTCGGCCAGTCGGGGGCTCTGGCCGGCTTGAACATGTGCGGAGCCGGGCGGGTAGTGTGCCTGATCGACCCGGTGGGTGACGTGTATGCGTGCCCATTCGCCATTCATGACCACTTCTTAGCCGGAAACGTGTTGTCCGACGGCGGATTTCAAAATGTCTGGAAGAACTCGTCGCTGTTTCGCGAGCTCCGGGAGCCCCAGTCCGCAGGCGCCTGTGGCAGCTGCGGACACTACGACAGCTGCCGGGGCGGCTGCATGGCGGCGAAATTCTTCACCGGCCTGCCGCTGGACGGGCCGGATCCCGAATGCGTGCAAGGCCATAGCGAGCCGGCGCTGGCGCGCGAGCGCCACCTACCGCGGCCCCGCGCCGACCACTCCCGCGGTCGGCGCGTCAGCAAACCGGTGCCCCTGACGCTGTCGATGCGGCCACCCAAGCGCCCGTGCAATGAAAGTCCGGTGTAG
- Drug Resistance
- Mutations
- Function
- May function to modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.
- Family
-
Radical SAM superfamily
- GO
-
- metal ion binding GO:0046872 molecular_function
- plasma membrane GO:0005886 cellular_component
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- transferase activity GO:0016740 molecular_function
- InterPro
Summary
- Name
- Putative mycofactocin radical SAM maturase MftC (EC 2.-.-.-)
- Family
- Radical SAM superfamily
- Protein Sequence
-
MTSPVPRLIEQFERGLDAPICLTWELTYACNLACVHCLSSSGKRDPGELSTRQCKDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNGVRITPEVATRLAATDYVDVQISLDGATAEVNDAIRGTGSFDMAVRALQNLAAAGFAGVKISVVITRRNVAQLDEFATLASRYGATLRITRLRPSGRGTDVWADLHPTADQQVQLYDWLVSKGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDVYACPFAIHDHFLAGNVLSDGGFQNVWKNSSLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPLDGPDPECVQGHSEPALARERHLPRPRADHSRGRRVSKPVPLTLSMRPPKRPCNESPV
- Mass
- 42,448 Da
- Length
- 391 Aa
Rv0693 doesn't seem to be a targeted by any drug.
Rv0693 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
- BMC Genomics. 2011 Jan 11;12:21. doi: 10.1186/1471-2164-12-21.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.