Gene - combatTB X

lldD1

Type: protein_coding
Name: lldD1
Locus Name: Rv0694
Product: Possible L-lactate dehydrogenase (cytochrome) LldD1
Functional Category: Intermediary metabolism and respiration
Location: 793335..794525 (+ strand)
Gene Length: 1190 bp
Nucleotides: TGGCCGAAGCGTGGTTTGAAACGGTAGCCATCGCGCAGCAACGCGCGAAGCGGAGGCTGCCGAAATCGGTTTACTCGTCCCTGATTGCGGCCAGTGAAAAGGGAATCACGGTCGCCGACAATGTCGCAGCATTCAGCGAGCTCGGGTTCGCGCCGCACGTCATCGGGGCGACAGATAAACGTGACTTGTCGACGACCGTTATGGGGCAAGAAGTTTCGTTGCCAGTGATTATTTCGCCGACCGGTGTTCAGGCGGTCGATCCCGGCGGTGAAGTCGCCGTCGCGCGGGCCGCGGCCGCCCGGGGTACTGTGATGGGATTGTCCTCGTTTGCCAGCAAGCCGATCGAGGAGGTCATTGCCGCCAACCCCAAGACCTTCTTCCAGGTCTACTGGCAGGGCGGGCGCGACGCGCTCGCTGAACGCGTCGAACGGGCGCGGCAGGCCGGCGCGGTCGGCCTGGTCGTCACCACCGACTGGACGTTCTCGCACGGGCGCGACTGGGGCAGCCCCAAGATCCCCGAAGAGATGAACTTGAAGACCATCCTGCGGCTATCCCCGGAGGCGATCACCCGGCCGAGGTGGTTGTGGAAGTTCGCCAAGACGCTACGGCCACCGGACCTACGGGTGCCCAACCAGGGCCGGCGCGGCGAGCCCGGCCCACCGTTCTTCGCAGCCTACGGCGAATGGATGGCAACACCTCCGCCGACCTGGGAAGATATCGGCTGGCTGCGCGAACTGTGGGGCGGACCGTTCATGCTCAAGGGCGTCATGCGGGTCGACGATGCCAAAAGAGCTGTGGATGCCGGGGTTTCGGCGATCTCGGTATCCAACCATGGTGGCAACAATTTGGATGGGACGCCAGCATCGATCCGGGCCCTGCCCGCGGTCTCGGCGGCGGTCGGCGATCAGGTCGAAGTGTTGCTCGACGGCGGCATCCGGCGGGGCAGCGATGTCGTCAAGGCGGTGGCGCTGGGCGCGCGCGCGGTAATGATTGGTCGCGCTTACCTGTGGGGCTTGGCCGCCAACGGCCAAGCCGGGGTCGAGAATGTACTCGACATCCTGCGCGGTGGTATCGACTCGGCTCTGATGGGTCTCGGGCATGCCTCTGTCCATGACCTCAGCCCAGCCGACATCCTCGTTCCCACCGGGTTCATCCGCGACCTGGGTGTGCCCTCCCGACGGGACGTTTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.

Family

FMN-dependent alpha-hydroxy acid dehydrogenase family

GO

FMN binding GO:0010181 molecular_function
plasma membrane GO:0005886 cellular_component
oxidoreductase activity GO:0016491 molecular_function

InterPro

UniProt: P9WND7
GenBank: Rv0694
EnsemblBacteria: Rv0694
Mycobrowser: Rv0694

Summary

Name: Putative mycofactocin system heme/flavin oxidoreductase MftD (EC 1.-.-.-)
Family: FMN-dependent alpha-hydroxy acid dehydrogenase family
Protein Sequence: MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANPKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV
Mass: 42,161 Da
Length: 396 Aa

Rv0694 doesn't seem to be a targeted by any drug.

Pyruvate metabolism mtu00620
mtu00620
PATHWAY_MAP mtu00620 Pyruvate metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.: BMC Genomics. 2011 Jan 11;12:21. doi: 10.1186/1471-2164-12-21.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.