Gene - combatTB X

Rv0695

Type: protein_coding
Name: Rv0695
Locus Name: Rv0695
Product: Conserved hypothetical protein
Functional Category: Conserved hypotheticals
Location: 794715..795470 (+ strand)
Gene Length: 755 bp
Nucleotides: TGAATTCGTCCTACCATCGGCGAGTGCCGGTAGTCGGGGAACTCGGGAGTGCGACGTCGAGCCAGCTACCAAGCACGTCGCCGTCGATAGTGATCCCGCTGGGGTCCACCGAGCAGCACGGTCCCCACCTGCCGTTAGATACCGATACCCGGATCGCGACCGCCGTGGCCCGGACCGTCACCGCGAGGCTGCACGCCGAGGACCTGCCCATTGCTCAGGAGGAATGGCTGATGGCGCCCGCCATTGCCTACGGCGCCAGCGGCGAACACCAGCGTTTCGCTGGAACGATCTCTATCGGCACTGAAGCCCTGACGATGTTGCTCGTGGAGTATGGCAGGTCGGCCGCCTGCTGGGCCCGGCGCCTGGTCTTCGTCAACGGGCACGGCGGCAATGTCGGCGCTTTGACCCGAGCGGTAGGCCTGCTGCGCGCTGAAGGTCGCGACGCCGGATGGTGCCCGTGCACCTGCCCGGGCGGTGACCCCCACGCCGGCCACACCGAAACATCCGTGCTGCTGCATCTTTCGCCGGCCGACGTGCGCACCGAACGGTGGCGCGCGGGTAATCGCGCACCGCTGCCCGTGTTGTTGCCGTCGATGCGCCGAGGCGGGGTCGCGGCCGTGAGCGAGACAGGAGTGCTCGGGGATCCGACCACGGCGACCGCGGCCGAGGGGCGGCGGATCTTCGCGGCGATGGTCGACGACTGTGTGCGCCGAGTCGCCCGGTGGATGCCACAGCCCGACGGGATGTTGACATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster.

Family

Creatininase superfamily

GO

metal ion binding GO:0046872 molecular_function
riboflavin biosynthetic process GO:0009231 biological_process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 molecular_function

InterPro

UniProt: P9WP59
GenBank: Rv0695
EnsemblBacteria: Rv0695
Mycobrowser: Rv0695

Summary

Name: Putative mycofactocin system creatinine amidohydrolase family protein MftE (EC 3.5.-.-)
Family: Creatininase superfamily
Protein Sequence: MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHLPLDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTEALTMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGDPHAGHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTTATAAEGRRIFAAMVDDCVRRVARWMPQPDGMLT
Mass: 26,580 Da
Length: 251 Aa

Rv0695 doesn't seem to be a targeted by any drug.

Rv0695 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.: BMC Genomics. 2011 Jan 11;12:21. doi: 10.1186/1471-2164-12-21.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.