Gene - combatTB X

rplC

Type: protein_coding
Name: rplC
Locus Name: Rv0701
Product: 50S ribosomal protein L3 RplC
Functional Category: Information pathways
Location: 800809..801462 (+ strand)
Gene Length: 653 bp
Nucleotides: TGGCACGAAAGGGCATTCTCGGTACCAAGCTGGGTATGACGCAGGTATTCGACGAAAGCAACAGAGTAGTACCGGTGACCGTGGTCAAGGCCGGGCCCAACGTGGTAACCCGCATCCGCACGCCCGAACGCGACGGTTATAGCGCCGTGCAGCTGGCCTATGGCGAGATCAGCCCACGCAAGGTCAACAAGCCGCTGACAGGTCAGTACACCGCCGCCGGCGTCAACCCACGCCGATACCTGGCGGAGCTGCGGCTGGACGACTCGGATGCCGCGACCGAGTACCAGGTTGGGCAAGAGTTGACCGCGGAGATCTTCGCCGATGGCAGCTACGTCGATGTGACGGGTACCTCCAAGGGCAAAGGTTTCGCCGGCACCATGAAGCGGCACGGCTTCCGCGGTCAGGGCGCCAGTCACGGTGCCCAGGCGGTGCACCGCCGTCCGGGCTCCATCGGCGGATGTGCCACGCCGGCGCGGGTGTTCAAGGGCACCCGGATGGCCGGGCGGATGGGCAATGACCGGGTGACCGTTCTTAACCTTTTGGTGCATAAGGTCGATGCCGAGAACGGCGTGCTGCTGATCAAGGGTGCGGTTCCTGGCCGCACCGGTGGACTGGTCATGGTCCGCAGTGCGATCAAACGAGGTGAGAAGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. {ECO:0000255|HAMAP-Rule:MF_01325}.

Family

Universal ribosomal protein uL3 family

GO

cytosolic large ribosomal subunit GO:0022625 cellular_component
structural constituent of ribosome GO:0003735 molecular_function
rRNA binding GO:0019843 molecular_function
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
translation GO:0006412 biological_process

InterPro

UniProt: P9WH87
GenBank: Rv0701
EnsemblBacteria: Rv0701
Mycobrowser: Rv0701

Summary

Name: 50S ribosomal protein L3
Family: Universal ribosomal protein uL3 family
Protein Sequence: MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK
Mass: 23,090 Da
Length: 217 Aa

Rv0701 doesn't seem to be a targeted by any drug.

Ribosome mtu03010
mtu03010
PATHWAY_MAP mtu03010 Ribosome

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.