Gene - combatTB X

rplD

Type: protein_coding
Name: rplD
Locus Name: Rv0702
Product: 50S ribosomal protein L4 RplD
Functional Category: Information pathways
Location: 801462..802133 (+ strand)
Gene Length: 671 bp
Nucleotides: TGGCTGCGCAAGAGCAGAAGACACTCAAAATCGACGTCAAGACGCCGGCGGGCAAGGTCGACGGCGCTATCGAGCTGCCGGCCGAGCTGTTCGACGTCCCGGCCAACATCGCGCTGATGCACCAGGTGGTCACCGCCCAGCGGGCGGCGGCACGCCAGGGTACCCACTCGACGAAGACGCGCGGCGAGGTCAGTGGCGGTGGCCGCAAGCCCTACCGGCAGAAGGGGACCGGTCGTGCCCGGCAGGGCTCGACGCGGGCGCCGCAGTTCACCGGCGGTGGCGTGGTACACGGTCCCAAGCCGCGCGACTACAGCCAGCGCACACCCAAGAAGATGATCGCCGCGGCGCTGCGCGGGGCGCTGTCCGACCGGGCCCGCAACGGGCGTATCCACGCGATCACCGAGCTAGTGGAAGGTCAAAACCCGTCGACCAAGAGCGCCAGGGCATTTCTGGCCAGCCTGACAGAACGTAAACAGGTGCTGGTGGTCATCGGGCGCAGCGACGAGGCCGGCGCGAAAAGCGTGCGCAATCTGCCGGGCGTGCACATCCTGGCGCCGGACCAGCTCAACACCTATGACGTGCTGCGTGCCGACGACGTGGTGTTCAGCGTTGAGGCGCTGAATGCCTATATCGCGGCCAACACCACGACGTCCGAGGAGGTTTCGGCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.; FUNCTION: Forms part of the polypeptide exit tunnel. {ECO:0000255|HAMAP-Rule:MF_01328}.

Family

Universal ribosomal protein uL4 family

GO

structural constituent of ribosome GO:0003735 molecular_function
rRNA binding GO:0019843 molecular_function
ribosome GO:0005840 cellular_component
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
translation GO:0006412 biological_process

InterPro

UniProt: P9WH85
GenBank: Rv0702
EnsemblBacteria: Rv0702
Mycobrowser: Rv0702

Summary

Name: 50S ribosomal protein L4
Family: Universal ribosomal protein uL4 family
Protein Sequence: MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVVTAQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQVLVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTSEEVSA
Mass: 23,743 Da
Length: 223 Aa

Rv0702 doesn't seem to be a targeted by any drug.

Ribosome mtu03010
mtu03010
PATHWAY_MAP mtu03010 Ribosome

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.