Gene - combatTB X

rplB

Type: protein_coding
Name: rplB
Locus Name: Rv0704
Product: 50S ribosomal protein L2 RplB
Functional Category: Information pathways
Location: 802528..803370 (+ strand)
Gene Length: 842 bp
Nucleotides: TGGCAATTCGCAAGTACAAGCCCACGACGCCTGGTCGTCGCGGCGCCAGCGTATCTGATTTCGCCGAGATCACCCGGTCAACCCCGGAGAAGTCGCTGGTGCGCCCGCTGCACGGTCGCGGTGGACGCAACGCGCATGGCCGGATTACCACCCGGCACAAAGGCGGCGGTCATAAGCGCGCTTACCGGATGATCGACTTTCGCCGCAATGACAAAGATGGTGTCAACGCCAAGGTCGCGCACATCGAGTACGACCCGAACCGTACCGCACGGATTGCGTTGCTCCACTATCTCGATGGGGAGAAGCGCTACATCATTGCACCCAACGGACTTTCGCAAGGGGATGTGGTGGAATCCGGCGCTAACGCCGACATCAAGCCGGGCAACAACCTGCCATTGCGCAACATCCCGGCCGGTACCTTGATCCACGCCGTGGAGCTCCGCCCGGGAGGTGGCGCTAAGCTTGCGCGCTCGGCCGGGTCGAGCATCCAGCTGCTCGGCAAGGAGGCCAGCTACGCGTCGCTGCGTATGCCCAGCGGTGAGATCCGCCGGGTCGACGTCCGCTGCCGCGCGACCGTCGGCGAAGTGGGCAATGCCGAGCAGGCAAACATCAACTGGGGCAAGGCCGGTCGGATGCGGTGGAAGGGCAAGCGCCCGTCGGTCCGGGGCGTGGTGATGAACCCGGTCGACCACCCGCACGGCGGTGGTGAGGGTAAGACCTCCGGCGGCCGTCACCCGGTTAGCCCGTGGGGCAAGCCTGAGGGGCGTACCCGCAATGCGAACAAGTCGAGCAACAAGTTCATCGTCCGACGCCGGCGCACCGGCAAGAAGCACTCGCGTTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01320}.

Family

Universal ribosomal protein uL2 family

GO

cytosolic large ribosomal subunit GO:0022625 cellular_component
structural constituent of ribosome GO:0003735 molecular_function
rRNA binding GO:0019843 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasmic translation GO:0002181 biological_process
transferase activity GO:0016740 molecular_function

InterPro

UniProt: P9WHA5
GenBank: Rv0704
EnsemblBacteria: Rv0704
Mycobrowser: Rv0704

Summary

Name: 50S ribosomal protein L2
Family: Universal ribosomal protein uL2 family
Protein Sequence: MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNAHGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSIQLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR
Mass: 30,577 Da
Length: 280 Aa

Rv0704 doesn't seem to be a targeted by any drug.

Ribosome mtu03010
mtu03010
PATHWAY_MAP mtu03010 Ribosome

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.