Gene - combatTB X

Rv0712

Type: protein_coding
Name: Rv0712
Locus Name: Rv0712
Product: Conserved protein
Functional Category: Conserved hypotheticals
Location: 808746..809645 (+ strand)
Gene Length: 899 bp
Nucleotides: TGCTGACCGAGTTGGTTGACCTGCCCGGCGGATCGTTCCGCATGGGCTCGACGCGCTTCTACCCCGAAGAAGCGCCGATTCATACCGTGACCGTGCGCGCCTTTGCGGTAGAGCGACACCCGGTGACCAACGCGCAATTTGCCGAATTCGTCTCCGCGACAGGCTATGTGACGGTTGCAGAACAACCCCTTGACCCCGGGCTCTACCCAGGAGTGGACGCAGCAGACCTGTGTCCCGGTGCGATGGTGTTTTGTCCGACGGCCGGGCCGGTCGACCTGCGTGACTGGCGGCAATGGTGGGACTGGGTACCTGGCGCCTGCTGGCGCCATCCGTTTGGCCGGGACAGCGATATCGCCGACCGAGCCGGCCACCCGGTCGTACAGGTGGCCTATCCGGACGCCGTGGCCTACGCACGATGGGCTGGTCGACGCCTACCGACCGAGGCCGAGTGGGAGTACGCGGCCCGTGGCGGAACCACGGCAACCTATGCGTGGGGCGACCAGGAGAAGCCGGGGGGCATGCTCATGGCGAACACCTGGCAGGGCCGGTTTCCTTACCGCAACGACGGTGCATTGGGCTGGGTGGGAACCTCCCCGGTGGGCAGGTTTCCGGCCAACGGGTTTGGCTTGCTCGACATGATCGGAAACGTTTGGGAGTGGACCACCACCGAGTTCTATCCACACCATCGCATCGATCCACCCTCGACGGCCTGCTGCGCACCGGTCAAGCTCGCTACAGCCGCCGACCCGACGATCAGCCAGACCCTCAAGGGCGGCTCGCACCTGTGCGCGCCGGAGTACTGCCACCGCTACCGCCCGGCGGCGCGCTCGCCGCAGTCGCAGGACACCGCGACCACCCATATCGGGTTCCGGTGCGTGGCCGACCCGGTGTCCGGGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. {ECO:0000269|PubMed:18390551}.

Family

Sulfatase-modifying factor family

GO

metal ion binding GO:0046872 molecular_function
Formylglycine-generating oxidase activity GO:0120147 molecular_function
protein oxidation GO:0018158 biological_process
post-translational protein modification GO:0043687 biological_process

InterPro

UniProt: I6Y8I5
GenBank: Rv0712
EnsemblBacteria: Rv0712
Mycobrowser: Rv0712

Summary

Name: Formylglycine-generating enzyme (FGE) (EC 1.8.3.7)
Family: Sulfatase-modifying factor family
Protein Sequence: MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTTATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCAPVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG
Mass: 32,744 Da
Length: 299 Aa

Rv0712 doesn't seem to be a targeted by any drug.

Rv0712 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Function and structure of a prokaryotic formylglycine-generating enzyme.: J Biol Chem. 2008 Jul 18;283(29):20117-25. doi: 10.1074/jbc.M800217200. Epub 2008 Apr 4.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.