Gene - combatTB X

rplF

Type: protein_coding
Name: rplF
Locus Name: Rv0719
Product: 50S ribosomal protein L6 RplF
Functional Category: Information pathways
Location: 813398..813937 (+ strand)
Gene Length: 539 bp
Nucleotides: TGTCGCGTATTGGTAAGCAGCCGATTCCGGTGCCCGCCGGGGTCGACGTCACGATCGAGGGACAGAGCATCTCGGTTAAGGGGCCCAAGGGCACCCTAGGACTGACGGTCGCCGAGCCAATCAAAGTGGCACGCAATGACGACGGCGCTATCGTGGTCACCCGTCCCGACGATGAGCGGCGTAATCGCTCCTTACACGGGCTGTCCCGTACCCTGGTGTCCAACCTGGTCACTGGCGTGACGCAGGGGTACACCACCAAGATGGAGATCTTCGGGGTTGGCTATCGGGTGCAGCTCAAGGGCTCCAATCTGGAGTTTGCGCTGGGGTACAGCCACCCGGTGGTGATCGAGGCTCCCGAAGGAATCACGTTCGCCGTCCAGGCACCGACGAAGTTCACCGTTTCCGGGATCGACAAACAAAAAGTCGGCCAGATCGCCGCCAATATCCGCCGTCTTCGCCGTCCCGATCCGTACAAGGGCAAGGGCGTGCGCTACGAGGGCGAGCAGATCCGCCGCAAGGTCGGAAAGACAGGTAAGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. {ECO:0000255|HAMAP-Rule:MF_01365}.

Family

Universal ribosomal protein uL6 family

GO

cytosolic large ribosomal subunit GO:0022625 cellular_component
structural constituent of ribosome GO:0003735 molecular_function
rRNA binding GO:0019843 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
cytoplasmic translation GO:0002181 biological_process

InterPro

UniProt: P9WH81
GenBank: Rv0719
EnsemblBacteria: Rv0719
Mycobrowser: Rv0719

Summary

Name: 50S ribosomal protein L6
Family: Universal ribosomal protein uL6 family
Protein Sequence: MSRIGKQPIPVPAGVDVTIEGQSISVKGPKGTLGLTVAEPIKVARNDDGAIVVTRPDDERRNRSLHGLSRTLVSNLVTGVTQGYTTKMEIFGVGYRVQLKGSNLEFALGYSHPVVIEAPEGITFAVQAPTKFTVSGIDKQKVGQIAANIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK
Mass: 19,377 Da
Length: 179 Aa

Rv0719 doesn't seem to be a targeted by any drug.

Ribosome mtu03010
mtu03010
PATHWAY_MAP mtu03010 Ribosome

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.