Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. {ECO:0000255|HAMAP-Rule:MF_01465}.

Family

SecY/SEC61-alpha family

GO

• signal sequence binding GO:0005048 molecular_function
• extracellular region GO:0005576 cellular_component
• integral component of plasma membrane GO:0005887 cellular_component
• protein transmembrane transporter activity GO:0008320 molecular_function
• plasma membrane GO:0005886 cellular_component
• evasion or tolerance by symbiont of host-produced reactive oxygen species GO:0052059 biological_process
• cell envelope Sec protein transport complex GO:0031522 cellular_component
• protein transport by the Sec complex GO:0043952 biological_process
• SRP-dependent cotranslational protein targeting to membrane, translocation GO:0006616 biological_process

InterPro

• IPR026593
• IPR002208
• IPR030659
• IPR023201

UniProt

P9WGN3

GenBank

Rv0732

EnsemblBacteria

Rv0732

Mycobrowser

Rv0732

Rv0732 doesn't seem to be a targeted by any drug.

• 

  Tolerance of reactive oxygen produced by macrophages R-HSA-1222387

  Homo sapiens

  R-HSA-1222387

• 

  Bacterial secretion system mtu03070

  mtu03070

  Environmental Information Processing; Membrane transport

• 

  Protein export mtu03060

  mtu03060

  Genetic Information Processing; Folding, sorting and degradation

• 

  Quorum sensing mtu02024

  mtu02024

  Cellular Processes; Cellular community - prokaryotes