Function

Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis (PubMed:20176745). Involved in resistance to oxidative stress, via TLR2-dependent activation of the PI3K-ERK1/2-NF-kappa-B signaling pathway and expression of COX-2 and Bcl2. Also abolishes H(2)O(2)-triggered activation of p38 MAPK (PubMed:20558725). {ECO:0000269|PubMed:20176745, ECO:0000269|PubMed:20558725}.

Family

Mycobacterial PE family, PGRS subfamily; Phosphoglycerate mutase family

GO

• cell surface GO:0009986 cellular_component
• pathogenesis GO:0009405 biological_process
• magnesium ion binding GO:0000287 molecular_function
• glycolytic process GO:0006096 biological_process
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component
• response to hypoxia GO:0001666 biological_process
• phosphoglycerate mutase activity GO:0004619 molecular_function

InterPro

• IPR000084
• IPR029033
• IPR013078

UniProt

Q79FW5

GenBank

Rv0754

EnsemblBacteria

Rv0754

Mycobrowser

Rv0754

Rv0754 doesn't seem to be a targeted by any drug.

Rv0754 doesn't seem to be involved in any pathway.