Gene - combatTB X

phoR

Type: protein_coding
Name: phoR
Locus Name: Rv0758
Product: Possible two component system response sensor kinase membrane associated PhoR
Functional Category: Regulatory proteins
Location: 852396..853853 (+ strand)
Gene Length: 1457 bp
Nucleotides: TGGCCAGACACCTTCGAGGAAGGCTGCCCCTACGGGTACGCCTGGTCGCAGCCACGCTGATCCTGGTGGCCACTGGACTTGTGGCCTCGGGGATCGCGGTCACCTCGATGTTGCAGCACCGGCTGACCAGCCGGATCGATCGGGTGTTGCTCGAGGAAGCCCAAATCTGGGCGCAGATCACGCTGCCCTTGGCGCCGGACCCCTACCCTGGTCATAACCCCGATCGGCCGCCGTCGAGGTTCTACGTTCGGGTGATCAGCCCCGACGGCCAGAGCTATACGGCACTCAACGACAACACTGCCATACCGGCGGTGCCCGCCAACAATGATGTCGGCCGGCACCCGACGACGCTGCCATCGATCGGCGGATCCAAGACTTTATGGCGCGCGGTCTCGGTGCGCGCGTCGGATGGCTACTTGACCACCGTCGCCATTGATCTGGCCGACGTCCGGAGCACCGTGCGGTCACTGGTGCTGTTGCAGGTCGGCATAGGCAGTGCGGTGCTGGTTGTCCCCGGGGTGGCGGGCTACGCTGTGGTTCGCCGCAGCCTGCGGCCGCTGGCAGAATTCGAGCAGACGGCCGCGGCGATCGGCGCGGGGCAGCTGGATCGCCGGGTCCCGCAGTGGCATCCGCGAACTGAGGTCGGCCGGCTTTCGTTGGCGCTCAACGGAATGCTGGCACAAATTCAGCGGGCGGTGGCGTCCGCGGAATCTTCCGCCGAAAAGGCCCGGGATTCAGAGGACCGGATGCGACAGTTCATCACCGACGCCAGCCATGAACTGCGTACCCCGTTGACCACTATCCGCGGCTTCGCGGAGCTGTACCGACAAGGAGCCGCCCGCGACGTGGGCATGCTGCTGTCGCGGATTGAGAGCGAAGCGAGCCGGATGGGGCTGCTGGTGGACGATTTGCTGCTGCTTGCCCGGCTAGATGCGCACCGGCCGTTGGAACTGTGCCGGGTGGACCTGCTGGCGCTGGCCAGTGATGCCGCGCACGACGCGCGGGCGATGGACCCCAAACGCAGGATCACCCTGGAGGTCCTTGACGGCCCCGGCACCCCGGAGGTCCTCGGCGACGAATCGCGGCTTCGGCAGGTGCTGCGCAATCTCGTTGCAAATGCCATACAGCACACCCCGGAAAGCGCCGACGTCACCGTGCGAGTCGGCACCGAGGGCGACGACGCCATCCTCGAGGTCGCCGATGACGGTCCGGGCATGAGTCAGGAGGATGCGCTGCGGGTGTTCGAGCGGTTCTATCGCGCCGACTCGTCGCGGGCGCGCGCCAGCGGCGGGACCGGACTGGGGTTGTCGATCGTCGACTCTTTGGTGGCGGCCCATGGCGGAGCGGTCACCGTGACGACCGCGCTCGGGGAGGGTTGCTGCTTTCGTGTCTCGCTGCCGCGCGTCAGTGACGTGGACCAGCTGAGCCTCACGCCAGTTGTGCCAGGGCCGCCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
phosphorelay sensor kinase activity GO:0000155 molecular_function
phosphorelay signal transduction system GO:0000160 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P71815
GenBank: Rv0758
EnsemblBacteria: Rv0758
Mycobrowser: Rv0758

Summary

Name: Possible two component system response sensor kinase membrane associated PhoR
Family: Unknown
Protein Sequence: MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP
Mass: 52,016 Da
Length: 485 Aa

Rv0758 doesn't seem to be a targeted by any drug.

Rv0758 doesn't seem to be involved in any pathway.

Asymmetric Structure of the Dimerization Domain of PhoR, a Sensor Kinase Important for the Virulence of Mycobacterium tuberculosis.: ACS Omega. 2017 Jul 31;2(7):3509-3517. doi: 10.1021/acsomega.7b00612. Epub 2017 Jul 12.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.