Gene - combatTB X

cpsY

Type: protein_coding
Name: cpsY
Locus Name: Rv0806c
Product: Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase)
Functional Category: Cell wall and cell processes
Location: 899732..901330 (- strand)
Gene Length: 1598 bp
Nucleotides: ATGCCCAAAATCTCTTCGCGCGACGGCGGTCGGCCCGCTCAGCGCACCGTGAATCCCATCATCGTTACCCGGCGCGGCAAGATCGCCCGCCTGGAATCCGGCCTGACCCCCCAGGAGGCCCAGATCGAAGATCTGGTCTTTCTGCGAAAGGTGTTAAACAGGGCTGATATTCCCTATCTACTGATCCGAAACCACAAGAACCGGCCGGTGCTTGCCATCAACATCGAACTACGTGCCGGCCTCGAGCGCGCTCTTGCGGCCGCATGTGCAACCGAACCGATGTACGCCAAAACTATTGATGAGCCTGGCCTTTCTCCTGTTTTGGTCGCCACCGACGGGCTGTCGCAGCTGGTTGACCCGCGTGTCGTGCGGTTGTATCGACGCCGGATCGCGCCGGGCGGATTTCGCTACGGCCCGGCGTTCGGTGTGGAACTGCAATTCTGGGTATACGAGGAGACGGTGATCCGCTGCCCTGTCGAAAACTCGCTTAGCCGCAAAGTGCTGCCCCGAAACGAAATAACGCCGACAAATGTCAAACTCTACGGGTACAAATGGCCGACCCTTGACGGGATGTTTGCCCCGCACGCCAGCGACGTCGTGTTCGACATAGACATGGTGTTCTCCTGGGTGGACGGTAGTGACCCCGAGTTCCGGGCGCGCCGCATGGCTCAAATGTCGCAGTACGTGGTGGGCGAGGGCGACGACGCCGAAGCGCGGATCCGCCAAATCGACGAGTTGAAATACGCGCTGCGGTCGGTGAACATGTTTGCTCCGTGGATACGTCGCATCTTCATCGCGACGGATTCAACCCCGCCGCCATGGTTGGCCGAACATCCTAAAATCACCATCGTTCGCGCCGAGGACCACTTTTCCGACCGTTCCGCGTTGCCGACCTATAACTCGCATGCGGTGGAGAGCCAGCTGCACCACATCCCGGGGCTCAGCGAGCACTTCTTGTACTCCAACGACGACATGTTCTTCGGCCGGCCGCTCAAGGCCAGTATGTTCTTCTCTCCCGGTGGAGTCACCAGGTTCATCGAAGCCAAGACCCGGATCGGGCTCGGCGCCAACAACCCAGCGCGTAGTGGCTTTGAAAACGCGGCCCGGGTAAACCGGCAGCTGCTCTTCGACCGGTTCGGGCAGGTGATTACCCGTCATCTCGAGCACACCGCGGTACCGTTGCGCAAGAGTGTGCTGATCGAGATGGAGCGGGAATTCCCGGAGGAATTCGCCCGCACCGCGGCCAGCCCGTTCCGCTCCGACACCGACATCTCGGTGACCAACTCGTTCTACCACTATTACGCGCTGATGACCGGACGCGCCGTCCCGCAGGAAAAGGCTAAAGTCCTCTATGTCGACACCACCAGCTATGCGGGTCTTCGGCTACTTCCTAAGTTGCGGAAGCACCGCGGATACGATTTCTTCTGCCTCAACGACGGTAGCTTTCCTGAAGTCCCCGCAGCGCAGCGCGCAGAACGAGTCGTCAGTTTCCTGGAGCGCTATTTCCCGATACCGGCTCCCTGGGAGAAGATCGCCGCGGACGTCAGTCGACGGGACTTCGCGGTGCCGAGGACGTCAGCACCATCGGAGGGTGCTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Stealth family

GO

polysaccharide biosynthetic process GO:0000271 biological_process
cell wall GO:0005618 cellular_component
transferase activity, transferring phosphorus-containing groups GO:0016772 molecular_function

InterPro

UniProt: P9WGD1
GenBank: Rv0806c
EnsemblBacteria: Rv0806c
Mycobrowser: Rv0806c

Summary

Name: Exopolysaccharide phosphotransferase CpsY (EC 2.7.-.-) (Stealth protein CpsY)
Family: Stealth family
Protein Sequence: MPKISSRDGGRPAQRTVNPIIVTRRGKIARLESGLTPQEAQIEDLVFLRKVLNRADIPYLLIRNHKNRPVLAINIELRAGLERALAAACATEPMYAKTIDEPGLSPVLVATDGLSQLVDPRVVRLYRRRIAPGGFRYGPAFGVELQFWVYEETVIRCPVENSLSRKVLPRNEITPTNVKLYGYKWPTLDGMFAPHASDVVFDIDMVFSWVDGSDPEFRARRMAQMSQYVVGEGDDAEARIRQIDELKYALRSVNMFAPWIRRIFIATDSTPPPWLAEHPKITIVRAEDHFSDRSALPTYNSHAVESQLHHIPGLSEHFLYSNDDMFFGRPLKASMFFSPGGVTRFIEAKTRIGLGANNPARSGFENAARVNRQLLFDRFGQVITRHLEHTAVPLRKSVLIEMEREFPEEFARTAASPFRSDTDISVTNSFYHYYALMTGRAVPQEKAKVLYVDTTSYAGLRLLPKLRKHRGYDFFCLNDGSFPEVPAAQRAERVVSFLERYFPIPAPWEKIAADVSRRDFAVPRTSAPSEGA
Mass: 60,268 Da
Length: 532 Aa

Rv0806c doesn't seem to be a targeted by any drug.

Amino sugar and nucleotide sugar metabolism mtu00520
mtu00520
PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism

Galactose metabolism mtu00052
mtu00052
PATHWAY_MAP mtu00052 Galactose metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.: PLoS Comput Biol. 2005 Nov;1(6):e63. doi: 10.1371/journal.pcbi.0010063. Epub 2005 Nov 18.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.