phoY2
- Type
- protein_coding
- Name
- phoY2
- Locus Name
-
Rv0821c
- Product
-
Probable phosphate-transport system transcriptional regulatory protein PhoY2
- Functional Category
-
Cell wall and cell processes
- Location
- 913558..914199 (- strand)
- Gene Length
- 641 bp
- Nucleotides
-
ATGCGGACCGCCTACCATGAGCAACTCTCGGAATTATCCGAGCGTCTCGGGGAAATGTGCGGGCTAGCAGGCATCGCCATGGAGCGGGCCACCCAAGCCTTGCTGCAGGCCGATCTCGTGCTGGCCGAGCAAGTGATCTCCGACCACGAAAAGATCGCGACGCTAAGCGCCCGGGCCGAGGAGAGTGCATTCGTTCTTCTGGCGTTGCAGGCACCGGTCGCCGGTGACCTCAGAGCCATTGTGAGCGCCATCCAGATGGTGGCTGACATCGACCGGATGGGGGCGTTGGCGCTGCATGTCGCCAAGATCGCCCGCCGTCGGCATCCACAGCACGCGCTGCCCGAAGAGGTCAACGGTTATTTTGCCGAAATGGGAAGAGTTGCAGTCGAATTGGGCAACAGTGCCCAAGAGGTCGTGTTGTCGCACGACCCGGAAAAGGCCGCCCAGATCCGCGAAGAAGACGACGCGATGGACGACCTGCACCGGCATTTGTTCACCGTGCTGATGGACCGCGAATGGAAGCACGGAGTGGCGGCCGCCGTCGACGTGACGTTGCTGAGCCGATTCTACGAGCGCTTTGCCGACCACGCCGTGGAAGTGGCACGACGCGTGATCTTCCAGGCGACCGGCGCCTTTCCCTA
- Drug Resistance
- Mutations
- Function
- Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit formation of the PhoR-PhoP transitory complex (By similarity). Important for tolerance to antibiotics. {ECO:0000250, ECO:0000269|PubMed:20360062}.
- Family
-
PhoU family
- GO
-
- response to antibiotic GO:0046677 biological_process
- dormancy process GO:0022611 biological_process
- cellular phosphate ion homeostasis GO:0030643 biological_process
- protein homodimerization activity GO:0042803 molecular_function
- negative regulation of phosphate metabolic process GO:0045936 biological_process
- cytoplasm GO:0005737 cellular_component
- negative regulation of phosphate transmembrane transport GO:2000186 biological_process
- phosphate ion transport GO:0006817 biological_process
- InterPro
Summary
- Name
- Phosphate-specific transport system accessory protein PhoU homolog 2 (Pst system accessory protein PhoU homolog 2)
- Family
- PhoU family
- Protein Sequence
-
MRTAYHEQLSELSERLGEMCGLAGIAMERATQALLQADLVLAEQVISDHEKIATLSARAEESAFVLLALQAPVAGDLRAIVSAIQMVADIDRMGALALHVAKIARRRHPQHALPEEVNGYFAEMGRVAVELGNSAQEVVLSHDPEKAAQIREEDDAMDDLHRHLFTVLMDREWKHGVAAAVDVTLLSRFYERFADHAVEVARRVIFQATGAFP
- Mass
- 23,514 Da
- Length
- 213 Aa
Rv0821c doesn't seem to be a targeted by any drug.
Rv0821c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis.
- J Antimicrob Chemother. 2010 Jun;65(6):1237-42. doi: 10.1093/jac/dkq103. Epub 2010 Apr 1.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.