Gene - combatTB X

Rv0823c

Type: protein_coding
Name: Rv0823c
Locus Name: Rv0823c
Product: Possible transcriptional regulatory protein
Functional Category: Regulatory proteins
Location: 916477..917646 (- strand)
Gene Length: 1169 bp
Nucleotides: ATGAGCAGGAGGCGGGCAATCCAACCCAGCCCGGCGTTGCGCATCGGCCCGATCGAGCTCGCCAGCCCGGTTGTGCTGGCTCCGATGGCCGGTGTGACGAACGTCGCATTCCGGGCGCTGTGTCGTCAGCTGGAACAGTCGAAGGTCGGCACGGTCAGCGGACTGTATGTCTGCGAGATGGTGACCGCACGTGCGCTCATCGAGCGGCACCCGGTCACCATGCACATGACAACGTTCTCCGCGGACGAATCACCACGCTCGCTGCAGCTGTACACCGTCGATCCGGACACCACGTATGCGGCCGCTCGGATGATCGCTGGCGAAGGGTTAGCCGATCACATCGACATGAATTTCGGCTGCCCAGTGCCCAAAGTCACCAAGCGCGGCGGCGGGGCGGCGCTACCGTTCAAACGGCGGCTATTCGGTCAGATCGTGGCCGCGGCTGTGCGCGCCACCGAAGGCACCGATATACCGGTGACGGTCAAGTTTCGCATTGGCATCGATGACGCCCACCACACACATCTGGATGCCGGCCGCATCGCTGAGGCCGAAGGAGCCGCTGCGGTCGCGCTGCACGCCCGTACCGCGGCACAACGCTATTCCGGCACCGCCGACTGGGAACAGATCGCCCGGCTCAAGCAGCATGTCCGGACGATTCCGGTGCTCGGCAACGGCGACATCTACGATGCCGGCGACGCACTGGCCATGATGTCCACCACCGGCTGTGACGGCGTGGTCATCGGCCGTGGCTGCCTGGGCCGTCCCTGGCTATTTGCCGAGTTGTCCGCGGCTTTCACCGGCAGCCCGGCCCCCACCCCACCCACGCTCGGCGAAGTCGCCGACATCATCCGCCGTCACGGCACCTTGCTGGCCGCACACTTCGGCGAGGACAAGGGCATGCGCGATATCCGCAAGCACATCGCCTGGTATCTCCATGGCTTCCCGGCGGGCTCCGCGCTCCGGCGGGCGTTAGCAATGGTCAAGACGTTCGACGAGCTCGACTGCCTGCTGGACCGGTTGGACGGCACGGTACCGTTCCCGGACTCCGCGACTGGCGCCCGGGGCCGGCAGGGTTCCCCCGCCCGGGTGGCCCTTCCCGACGGCTGGCTAACCGACCCCGACGACTGCCGAGTGCCGGAAGGGGCGGACGCCATGGGGTCGGGTGGCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. {ECO:0000250|UniProtKB:P33371}.

Family

Dus family

GO

tRNA dihydrouridine synthase activity GO:0017150 molecular_function
flavin adenine dinucleotide binding GO:0050660 molecular_function
tRNA binding GO:0000049 molecular_function

InterPro

UniProt: P9WNS7
GenBank: Rv0823c
EnsemblBacteria: Rv0823c
Mycobrowser: Rv0823c

Summary

Name: Probable tRNA-dihydrouridine synthase (EC 1.3.1.-)
Family: Dus family
Protein Sequence: MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG
Mass: 41,388 Da
Length: 389 Aa

Rv0823c doesn't seem to be a targeted by any drug.

Rv0823c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.